Are melanin injections irreversible? – 2021


When you tan your whole body, you’re exposing all your skin to hazardous UV rays. If your skin frequently obtains revealed to UV rays too much, it’ll cause wellness problems as well as skin issues for you.

Thankfully, Melanotan peptide can aid you take care of these tanning issues by enabling your body to enhance its manufacturing of melanin. Whenever your body experiences UV damage, it normally reacts by producing melanin. This is a peptide hormone which normally darkens the skin in order to shield it from the harmful UV rays.


Suggestions on the use on injecting tanning representatives, e.g. Melanotan


Due to the current attention and also warnings concerning the threats of infusing melanotan the HSE has actually launched details and also advice on the usage on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medication (afamelanotide) which was developed by the College of Arizona in 1981 to be made use of for photo defense against sunlight damage. This medicine is currently going through clinical tests for usage in patients with particular sun-sensitive skin disease and is not offered for basic sale.

The medication is chemically related to the alpha-melanocyte stimulating hormone (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a crucial duty in determining skin and also hair coloring, enhances manufacturing of melanin in the skin, leading to a ‘sun tan’.

Melanotan is an artificial analog of α-MSH as well as is unlawful, untried and also unregulated which is currently being marketed online for self-administration. α-MSH is extremely fragile and calls for a strenuous production atmosphere which can not be assured in unlicensed manufacturing laboratories. The item needs to also be saved in a fridge.

What is the distinction in between Melanotan I and Melanotan II?

Melanotan I especially binds to receptors responsible for tanning and so has less adverse effects. Nonetheless far more of it is required for result and consequently it is much more costly than Melanotan II.

Melanotan II binds to receptors besides those in charge of tanning and therefore leads to more side-effects.

What are the side-effects?

As this is an unregulated as well as untried drug the full series of possible side-effects are unknown. Boosted sex drive, spontaneous erections, nausea or vomiting (with succeeding fat burning), face flushing on management, flu-like signs, and increased high blood pressure have actually been reported.

How is Melanotan provided?

Melanotan is administered subcutaneously by injecting right into the fatty layer of cells around the stubborn belly button area. Clients infuse daily up until a preferred colour is attained and afterwards continue to infuse one or two times a week to keep the colour.

Some dimming of the skin might occur utilizing the shot alone however the impacts are far more remarkable when utilized together with direct exposure to UV light (sun or tanning bed) 2-3 times a week originally and then 1-2 times a week after that.

Exactly how is Melanotan offered?

Products on the marketplace include:

  • A multi- dosage vial of 10, 20 or 30 doses for subcutaneous shot.
  • A collection of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key issues

Item purity and also content:

  • This is an unlicensed, uncontrolled product. This is a fragile drug which calls for refrigeration.
  • Users might reluctant to place the product in their family members refrigerator. If pre-filled syringes are positioned in the fridge this has effects in terms of accessibility of kids to syringes.

Unidentified side-effects:

  • There are no medical trials offered on the brief as well as long-term impacts of using these products or if the dosages advised by manufacturers are secure.
  • There is no trial data readily available on just how these products may communicate with various other drugs or their impact on a coming child.

Injecting equipment

  • Needles utilized to infuse can also lug bodily fluids, which can pass on infections such as HIV as well as liver disease. In many cases, there is an undersupply of needles by the on-line vendors for the amount of administration needed, e.g. 1 needle supplied with a 10 dosage vial.
  • This might lead to sharing as well as reusing of needles. There are records of customers utilizing the exact same needle for a month and also attempting to sterilise after every usage.
  • A multi-dose vial manufactured in a non-rigorous production setting might not remain sterilized for the duration of its use e.g. a 30mg vial is made to be used for 30 doses which might extend a period of 10 weeks.
  • Some sites supply pre-filled syringes in which the item is currently re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled items will certainly continue to be steady and clean and sterile throughout delivery or for the lifetime of their use.

Disposal of used sharps

There have actually been records of needles being taken care of in house rubbish.

Enhanced exposure to UV rays

As the impacts of the tanning agents are a lot more dramatic when made use of along with direct exposure to UV light (by natural sunlight or by tanning beds) use the representatives might raise UV exposure with all the addition dangers connected such as raised danger of skin cancer, skin ageing, etc

Injury decrease activities

  • Discuss to users concerning the dangers connected with injectable tanning items.
  • Highlight the threats connected with boosted UV exposure (the ill effects of sun tanning still happen even in customers that have a deep tan). Customers can speak to the Irish Cancer Culture if they have issues concerning skin cancer on the cancer cells helpline 1800 200 700 or
  • Encourage individuals to stop using, and also to seek clinical guidance if required.

If utilizing

Clean injecting tools:

  • Recommend that they use a tidy needle every time as well as deal with needles in a sharps container. The needles readily available in the injecting pack readily available in pharmacies participating in the Drug store Needle Exchange Program are designed like a diabetic needle and are suitable for subcutaneous injection.
  • Suggest clients on the risk of blood birthed conditions and use suggestions on whom to call if the client is concerned that they might have exposed themselves to a blood birthed illness by sharing needles.
  • A checklist of drug stores participating in your location is available via the Medications helpline 1800 459 459.

Safe disposal.

The pack likewise consists of a tiny sharps container for made use of sharps. Drug stores will accept made use of sharps if returned in the sharps container.

Pollutant as well as instability of item.

  • The amount of product in the vial may differ significantly, might be infected with germs or various other chemicals.
  • Inspect the vial prior to usage as well as do not use if discolored or if bits noticeable.
  • It should be saved in the refrigerator.
  • All drugs need to be kept out of the reach of children which may be challenging in a fridge.


  • Recommend that side-effects are unknown, and also the doses being utilized might not be risk-free.
  • Impacts of the medication on an unborn kid are unidentified.
  • Results when taken with various other drugs are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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