Do tanning injections work on reasonable skin? –

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Guidance on the usage on injecting tanning representatives, e.g. Melanotan


As a result of the recent publicity as well as cautions concerning the risks of injecting melanotan the HSE has actually released information and also advice on the use on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was created by the College of Arizona in 1981 to be utilized for image security against sun damages. This medication is currently undergoing professional tests for use in people with particular sun-sensitive skin problem and is not available for basic sale.

The medication is chemically associated with the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key role in determining skin as well as hair coloring, raises manufacturing of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH and is unlawful, untried and unregulated which is presently being marketed online for self-administration. α-MSH is extremely breakable and calls for a rigorous manufacturing setting which can not be assured in unlicensed production laboratories. The item has to likewise be stored in a fridge.

What is the difference in between Melanotan I and also Melanotan II?

Melanotan I especially binds to receptors in charge of tanning therefore has less side effects. However far more of it is needed for impact as well as as a result it is a lot more pricey than Melanotan II.

Melanotan II binds to receptors besides those responsible for tanning as well as as a result causes more side-effects.

What are the side-effects?

As this is an unregulated and untested medication the complete series of prospective side-effects are unidentified. Enhanced libido, spontaneous erections, nausea or vomiting (with succeeding weight loss), face flushing on management, flu-like signs and symptoms, and also raised high blood pressure have been reported.

How is Melanotan carried out?

Melanotan is carried out subcutaneously by infusing into the fatty layer of tissue around the tummy button area. Customers inject daily up until a preferred colour is attained and then continue to inject once or twice a week to maintain the colour.

Some dimming of the skin may occur using the shot alone however the impacts are even more remarkable when used along with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and then 1-2 times a week thereafter.

Exactly how is Melanotan available?

Products on the market consist of:

  • A multi- dosage vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main issues

Item purity and material:

  • This is an unlicensed, uncontrolled item. This is a vulnerable medicine which requires refrigeration.
  • Customers may reluctant to put the product in their family members fridge. If pre-filled syringes are positioned in the refrigerator this has ramifications in terms of gain access to of youngsters to syringes.

Unidentified side-effects:

  • There are no scientific trials offered on the brief and long term effects of using these items or if the doses suggested by producers are risk-free.
  • There is no trial information available on how these items may connect with other medications or their impact on an expected kid.

Injecting equipment

  • Needles utilized to inject might also carry bodily liquids, which can pass on infections such as HIV and liver disease. In some cases, there is an undersupply of needles by the online vendors for the quantity of management needed, e.g. 1 needle supplied with a 10 dosage vial.
  • This could cause sharing and recycling of needles. There are records of customers making use of the exact same needle for a month as well as attempting to sterilise after every use.
  • A multi-dose vial produced in a non-rigorous production setting might not continue to be clean and sterile for the duration of its use e.g. a 30mg vial is designed to be used for 30 doses which may extend an amount of time of 10 weeks.
  • Some websites provide pre-filled syringes in which the product is already re-constituted with bacteriostatic water, nevertheless there is no guarantee that these pre-filled items will certainly continue to be steady and also sterilized during distribution or for the life expectancy of their use.

Disposal of used sharps

There have actually been records of needles being taken care of in household rubbish.

Boosted direct exposure to UV rays

As the impacts of the tanning representatives are a lot more dramatic when made use of along with exposure to UV light (by natural sunlight or by tanning beds) use of the representatives might raise UV direct exposure with all the enhancement risks linked such as enhanced risk of skin cancer, skin ageing, and so on

Injury reduction actions

  • Explain to users about the risks associated with injectable tanning products.
  • Highlight the dangers associated with raised UV exposure (the sick effects of sun tanning still take place even in customers who have a deep tan). Customers can speak to the Irish Cancer cells Society if they have issues regarding skin cancer on the cancer cells helpline 1800 200 700 or
  • Motivate individuals to stop making use of, as well as to seek clinical guidance if needed.

If making use of

Tidy infusing tools:

  • Suggest that they utilize a clean needle every single time and deal with needles in a sharps container. The needles offered in the infusing pack offered in drug stores taking part in the Pharmacy Needle Exchange Program are developed like a diabetic person needle and appropriate for subcutaneous injection.
  • Suggest customers on the threat of blood borne diseases and also supply guidance on whom to contact if the customer is worried that they might have subjected themselves to a blood borne disease by sharing needles.
  • A checklist of drug stores participating in your area is readily available through the Medications helpline 1800 459 459.

Safe disposal.

The pack additionally contains a tiny sharps container for utilized sharps. Drug stores will certainly accept made use of sharps if returned in the sharps container.

Pollutant as well as instability of item.

  • The quantity of item in the vial may differ significantly, may be infected with bacteria or other chemicals.
  • Inspect the vial prior to usage as well as do not utilize if tarnished or if bits noticeable.
  • It needs to be saved in the refrigerator.
  • All drugs need to be shut out of the reach of youngsters which may be difficult in a fridge.


  • Advise that side-effects are unidentified, as well as the dosages being utilized may not be secure.
  • Impacts of the drug on an unborn kid are unknown.
  • Impacts when taken with other drugs are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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