Do you need to refrigerate Melanotan 2? – 2021


When you tan your entire body, you’re revealing all your skin to harmful UV rays. If your skin regularly obtains subjected to UV rays too much, it’ll trigger health and wellness concerns as well as skin issues for you.

Luckily, Melanotan peptide can aid you handle these tanning problems by permitting your body to raise its production of melanin. Whenever your body endures UV damage, it naturally responds by creating melanin. This is a peptide hormonal agent which naturally dims the skin in order to shield it from the destructive UV rays.


Recommendations on the use on injecting tanning agents, e.g. Melanotan


Due to the recent publicity and warnings regarding the dangers of injecting melanotan the HSE has actually released details and suggestions on the usage on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was created by the University of Arizona in 1981 to be made use of for picture defense versus sun damages. This medicine is currently undergoing scientific trials for use in individuals with particular sun-sensitive skin conditions as well as is not readily available for general sale.

The medication is chemically associated with the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential role in establishing skin as well as hair coloring, raises production of melanin in the skin, causing a ‘sun tan’.

Melanotan is an artificial analog of α-MSH as well as is prohibited, untried and also unregulated which is presently being sold online for self-administration. α-MSH is extremely delicate and requires an extensive production setting which can not be guaranteed in unlicensed manufacturing labs. The product must also be kept in a fridge.

What is the difference between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning therefore has less side effects. However a lot more of it is needed for impact as well as as a result it is much more pricey than Melanotan II.

Melanotan II binds to receptors apart from those in charge of tanning and consequently leads to more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untested drug the full series of prospective side-effects are unidentified. Boosted sex drive, spontaneous erections, queasiness (with subsequent weight-loss), facial flushing on administration, flu-like symptoms, and also boosted high blood pressure have actually been reported.

Exactly how is Melanotan carried out?

Melanotan is provided subcutaneously by infusing into the fatty layer of cells around the tummy button area. Customers inject daily up until a wanted colour is achieved and afterwards continue to inject once or twice a week to preserve the colour.

Some dimming of the skin might take place making use of the injection alone however the results are far more dramatic when made use of together with exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and after that 1-2 times a week after that.

Exactly how is Melanotan offered?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main worries

Product purity and also content:

  • This is an unlicensed, uncontrolled item. This is a delicate medicine which needs refrigeration.
  • Customers might unwilling to put the item in their household refrigerator. If pre-filled syringes are placed in the refrigerator this has ramifications in terms of gain access to of youngsters to syringes.

Unidentified side-effects:

  • There are no professional trials offered on the brief as well as long term effects of using these products or if the doses advised by suppliers are risk-free.
  • There is no test data offered on how these items might connect with various other medications or their effect on an unborn child.

Injecting devices

  • Needles utilized to infuse could also lug bodily liquids, which can pass on infections such as HIV and also hepatitis. In many cases, there is an undersupply of needles by the on-line providers for the quantity of management needed, e.g. 1 needle provided with a 10 dose vial.
  • This could bring about sharing and also reusing of needles. There are reports of customers utilizing the same needle for a month and trying to sterilise after every usage.
  • A multi-dose vial manufactured in a non-rigorous manufacturing atmosphere might not remain sterile throughout of its use e.g. a 30mg vial is made to be made use of for 30 dosages which may cover an amount of time of 10 weeks.
  • Some websites provide pre-filled syringes in which the product is already re-constituted with bacteriostatic water, however there is no assurance that these pre-filled products will certainly stay stable and also sterile throughout delivery or for the lifetime of their usage.

Disposal of used sharps

There have actually been records of needles being dealt with in household rubbish.

Enhanced direct exposure to UV rays

As the results of the tanning agents are much more dramatic when made use of along with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the agents may increase UV exposure with all the addition risks linked such as increased threat of skin cancer, skin ageing, etc

Damage reduction activities

  • Clarify to users concerning the risks associated with injectable tanning items.
  • Highlight the dangers associated with boosted UV exposure (the sick results of tanning still occur even in customers that have a deep tan). Clients can contact the Irish Cancer Culture if they have worries regarding skin cancer cells on the cancer cells helpline 1800 200 700 or
  • Motivate customers to quit making use of, as well as to look for medical advice if required.

If utilizing

Clean infusing devices:

  • Advise that they use a tidy needle whenever as well as throw away needles in a sharps container. The needles offered in the infusing pack available in pharmacies joining the Drug store Needle Exchange Program are designed like a diabetic person needle and are suitable for subcutaneous injection.
  • Recommend customers on the danger of blood borne illness and also use suggestions on whom to contact if the customer is worried that they might have exposed themselves to a blood borne disease by sharing needles.
  • A checklist of pharmacies taking part in your location is readily available with the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally has a small sharps container for used sharps. Pharmacies will certainly approve made use of sharps if returned in the sharps container.

Impurity and instability of product.

  • The quantity of product in the vial may differ significantly, may be polluted with germs or various other chemicals.
  • Examine the vial prior to usage and also do not use if stained or if particles noticeable.
  • It has to be kept in the refrigerator.
  • All medicines ought to be shut out of the reach of kids which might be tough in a fridge.


  • Suggest that side-effects are unknown, and the dosages being used may not be safe.
  • Results of the drug on an unborn kid are unknown.
  • Impacts when taken with other medicines are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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