Does Melanotan 2 make blemishes darker? – 2021

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Suggestions on the use on infusing tanning agents, e.g. Melanotan


As a result of the current promotion and cautions concerning the risks of infusing melanotan the HSE has actually released details and suggestions on the use on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was established by the College of Arizona in 1981 to be utilized for picture security against sun damage. This medication is currently undertaking clinical tests for usage in clients with certain sun-sensitive skin disease and is not available for general sale.

The medication is chemically connected to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key role in establishing skin as well as hair coloring, raises production of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH and also is unlawful, untested and also unregulated which is presently being marketed online for self-administration. α-MSH is really fragile and also requires a rigorous production atmosphere which can not be guaranteed in unlicensed manufacturing laboratories. The item must likewise be kept in a fridge.

What is the distinction between Melanotan I as well as Melanotan II?

Melanotan I particularly binds to receptors responsible for tanning therefore has less negative effects. Nonetheless much more of it is required for impact and as a result it is extra expensive than Melanotan II.

Melanotan II binds to receptors other than those responsible for tanning as well as therefore leads to even more side-effects.

What are the side-effects?

As this is an uncontrolled and also untested drug the full range of prospective side-effects are unidentified. Boosted sex drive, spontaneous erections, nausea or vomiting (with succeeding weight reduction), facial flushing on management, flu-like signs, and enhanced high blood pressure have actually been reported.

Just how is Melanotan carried out?

Melanotan is provided subcutaneously by infusing into the fatty layer of cells around the belly button area. Customers infuse daily until a desired colour is accomplished and afterwards remain to inject once or twice a week to keep the colour.

Some darkening of the skin might occur using the injection alone yet the results are even more remarkable when made use of along with exposure to UV light (sunlight or tanning bed) 2-3 times a week initially and afterwards 1-2 times a week afterwards.

How is Melanotan offered?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Key problems

Item purity as well as web content:

  • This is an unlicensed, unregulated item. This is a breakable medicine which requires refrigeration.
  • Individuals might hesitant to position the item in their family fridge. If pre-filled syringes are positioned in the refrigerator this has effects in terms of accessibility of kids to syringes.

Unidentified side-effects:

  • There are no medical trials readily available on the short as well as long-term impacts of using these items or if the doses suggested by producers are risk-free.
  • There is no trial information offered on how these products may communicate with various other drugs or their impact on an unborn kid.

Injecting devices

  • Needles used to infuse can additionally bring bodily liquids, which can hand down infections such as HIV and also liver disease. Sometimes, there is an undersupply of needles by the on the internet providers for the quantity of administration called for, e.g. 1 needle provided with a 10 dose vial.
  • This might result in sharing and recycling of needles. There are reports of customers utilizing the same needle for a month as well as attempting to sterilise after every use.
  • A multi-dose vial produced in a non-rigorous production environment may not stay sterile throughout of its usage e.g. a 30mg vial is designed to be used for 30 doses which might span a time period of 10 weeks.
  • Some sites provide pre-filled syringes in which the item is already re-constituted with bacteriostatic water, nevertheless there is no warranty that these pre-filled products will stay stable and also sterile during delivery or for the life span of their use.

Disposal of used sharps

There have been records of needles being gotten rid of in family rubbish.

Raised exposure to UV rays

As the effects of the tanning agents are more significant when used combined with direct exposure to UV light (by natural sunlight or by tanning beds) use of the representatives might increase UV exposure with all the enhancement threats linked such as boosted threat of skin cancer, skin ageing, etc

Injury decrease actions

  • Explain to users about the threats connected with injectable tanning products.
  • Highlight the dangers related to increased UV direct exposure (the ill impacts of tanning still take place also in clients who have a deep tan). Clients can get in touch with the Irish Cancer Society if they have issues regarding skin cancer cells on the cancer helpline 1800 200 700 or
  • Motivate users to quit utilizing, and also to look for clinical recommendations if needed.

If making use of

Clean infusing tools:

  • Advise that they utilize a clean needle each time and also throw away needles in a sharps container. The needles readily available in the infusing pack readily available in pharmacies taking part in the Pharmacy Needle Exchange Program are designed like a diabetic person needle and also appropriate for subcutaneous shot.
  • Suggest clients on the danger of blood birthed diseases and supply suggestions on whom to call if the customer is concerned that they may have subjected themselves to a blood birthed illness by sharing needles.
  • A list of pharmacies taking part in your area is offered via the Medicines helpline 1800 459 459.

Safe disposal.

The pack likewise consists of a little sharps container for made use of sharps. Drug stores will certainly accept made use of sharps if returned in the sharps container.

Pollutant as well as instability of product.

  • The amount of item in the vial may differ significantly, might be infected with microorganisms or various other chemicals.
  • Inspect the vial before usage as well as do not use if blemished or if bits noticeable.
  • It must be saved in the fridge.
  • All drugs ought to be stayed out of the reach of kids which might be hard in a refrigerator.


  • Suggest that side-effects are unidentified, and the dosages being used might not be secure.
  • Effects of the drug on a coming youngster are unidentified.
  • Effects when taken with various other medicines are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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