Does Melanotan 2 work without sunlight? – 2021


When you tan your entire body, you’re revealing all your skin to hazardous UV rays. If your skin regularly obtains revealed to UV rays excessive, it’ll create wellness problems and also skin issues for you.

Thankfully, Melanotan peptide can help you handle these tanning concerns by allowing your body to boost its production of melanin. Whenever your body endures UV damages, it normally reacts by producing melanin. This is a peptide hormonal agent which naturally dims the skin in order to protect it from the harmful UV rays.


Advice on the use on infusing tanning agents, e.g. Melanotan


As a result of the current attention as well as warnings about the threats of infusing melanotan the HSE has released info and advice on the use on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was created by the University of Arizona in 1981 to be utilized for photo security against sun damages. This medicine is currently going through medical tests for usage in clients with certain sun-sensitive skin disease as well as is not readily available for basic sale.

The drug is chemically related to the alpha-melanocyte stimulating hormone (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a crucial role in determining skin and hair pigmentation, increases production of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is a synthetic analog of α-MSH and is illegal, untried and uncontrolled which is currently being marketed online for self-administration. α-MSH is very vulnerable and also calls for an extensive production atmosphere which can not be guaranteed in unlicensed production laboratories. The item must likewise be kept in a refrigerator.

What is the distinction between Melanotan I and Melanotan II?

Melanotan I particularly binds to receptors responsible for tanning and so has less adverse effects. Nevertheless a lot more of it is required for result as well as consequently it is extra pricey than Melanotan II.

Melanotan II binds to receptors other than those responsible for tanning and also therefore leads to even more side-effects.

What are the side-effects?

As this is an uncontrolled and untested medication the full variety of potential side-effects are unknown. Raised libido, spontaneous erections, nausea or vomiting (with subsequent weight management), facial flushing on management, flu-like symptoms, as well as boosted blood pressure have been reported.

Just how is Melanotan provided?

Melanotan is carried out subcutaneously by infusing into the fatty layer of cells around the stomach button area. Clients infuse daily up until a desired colour is attained and then continue to infuse once or twice a week to keep the colour.

Some darkening of the skin may occur using the injection alone yet the effects are even more dramatic when used together with exposure to UV light (sun or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week afterwards.

Exactly how is Melanotan readily available?

Products on the marketplace consist of:

  • A multi- dosage vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key problems

Item purity and also content:

  • This is an unlicensed, uncontrolled item. This is a vulnerable medication which needs refrigeration.
  • Individuals might reluctant to put the product in their family refrigerator. If pre-filled syringes are positioned in the refrigerator this has ramifications in regards to accessibility of kids to syringes.

Unknown side-effects:

  • There are no clinical trials available on the short and also long term effects of using these products or if the doses recommended by suppliers are risk-free.
  • There is no test information available on just how these products might communicate with various other drugs or their impact on an expected kid.

Injecting devices

  • Needles made use of to inject might also carry bodily liquids, which can pass on infections such as HIV and liver disease. In some cases, there is an undersupply of needles by the on-line vendors for the amount of management required, e.g. 1 needle supplied with a 10 dose vial.
  • This can lead to sharing and recycling of needles. There are reports of clients utilizing the same needle for a month and also attempting to sterilise after every use.
  • A multi-dose vial made in a non-rigorous production setting might not stay sterilized throughout of its use e.g. a 30mg vial is created to be utilized for 30 doses which may span a time period of 10 weeks.
  • Some websites use pre-filled syringes in which the item is already re-constituted with bacteriostatic water, however there is no assurance that these pre-filled products will certainly continue to be stable as well as clean and sterile throughout distribution or for the life expectancy of their use.

Disposal of used sharps

There have actually been records of needles being thrown away in family rubbish.

Increased exposure to UV rays

As the effects of the tanning agents are much more remarkable when used together with exposure to UV light (by natural sunshine or by tanning beds) use of the agents might enhance UV direct exposure with all the enhancement threats connected such as enhanced risk of skin cancer cells, skin ageing, etc

Injury decrease actions

  • Describe to customers about the risks connected with injectable tanning products.
  • Highlight the risks associated with enhanced UV direct exposure (the ill results of tanning still take place also in clients who have a deep tan). Customers can contact the Irish Cancer cells Culture if they have issues pertaining to skin cancer cells on the cancer cells helpline 1800 200 700 or
  • Urge users to quit making use of, as well as to look for medical suggestions if needed.

If making use of

Tidy infusing equipment:

  • Recommend that they make use of a tidy needle whenever and also get rid of needles in a sharps container. The needles available in the infusing pack readily available in drug stores participating in the Pharmacy Needle Exchange Program are made like a diabetic needle and appropriate for subcutaneous injection.
  • Suggest customers on the risk of blood borne conditions and also use guidance on whom to call if the customer is concerned that they may have subjected themselves to a blood borne disease by sharing needles.
  • A list of drug stores participating in your location is available via the Drugs helpline 1800 459 459.

Safe disposal.

The pack additionally contains a little sharps container for utilized sharps. Pharmacies will accept used sharps if returned in the sharps container.

Impurity and also instability of item.

  • The amount of product in the vial might vary significantly, might be infected with microorganisms or other chemicals.
  • Inspect the vial before usage and do not utilize if discolored or if fragments noticeable.
  • It has to be stored in the refrigerator.
  • All medications should be stayed out of the reach of kids which may be tough in a refrigerator.


  • Advise that side-effects are unidentified, and the doses being utilized might not be safe.
  • Results of the medicine on an expected kid are unknown.
  • Effects when taken with various other drugs are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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