Does Melanotan assist weight loss? –

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When you tan your entire body, you’re revealing all your skin to harmful UV rays. If your skin consistently gets exposed to UV rays excessive, it’ll trigger health issues and also skin concerns for you.

The good news is, Melanotan peptide can aid you manage these tanning issues by permitting your body to increase its manufacturing of melanin. Whenever your body experiences UV damage, it naturally reacts by creating melanin. This is a peptide hormonal agent which normally darkens the skin in order to protect it from the destructive UV rays.


Guidance on the use on infusing tanning agents, e.g. Melanotan


As a result of the recent promotion and also cautions concerning the risks of infusing melanotan the HSE has actually launched details and also advice on the usage on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was created by the College of Arizona in 1981 to be made use of for picture defense versus sunlight damage. This drug is presently undergoing scientific trials for usage in individuals with particular sun-sensitive skin problem as well as is not available for general sale.

The drug is chemically related to the alpha-melanocyte stimulating hormone (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key role in identifying skin and hair coloring, increases production of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is a synthetic analog of α-MSH and is unlawful, untested and unregulated which is currently being offered online for self-administration. α-MSH is really fragile as well as needs an extensive production environment which can not be assured in unlicensed production labs. The item must likewise be saved in a refrigerator.

What is the distinction in between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning therefore has less negative effects. Nevertheless much more of it is needed for effect and for that reason it is extra costly than Melanotan II.

Melanotan II binds to receptors other than those responsible for tanning and as a result causes more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untried medicine the complete range of prospective side-effects are unknown. Enhanced sex drive, spontaneous erections, nausea or vomiting (with subsequent weight management), facial flushing on administration, flu-like symptoms, and also enhanced blood pressure have been reported.

How is Melanotan administered?

Melanotan is carried out subcutaneously by infusing into the fatty layer of tissue around the stomach switch location. Customers infuse daily up until a preferred colour is attained and then remain to inject one or two times a week to keep the colour.

Some darkening of the skin may take place making use of the injection alone but the results are much more dramatic when made use of together with direct exposure to UV light (sun or tanning bed) 2-3 times a week originally and afterwards 1-2 times a week thereafter.

Exactly how is Melanotan available?

Products on the marketplace consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous shot.
  • A collection of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main worries

Item pureness and also material:

  • This is an unlicensed, uncontrolled product. This is a delicate medication which requires refrigeration.
  • Individuals may unwilling to position the item in their family members fridge. If pre-filled syringes are put in the fridge this has ramifications in regards to gain access to of kids to syringes.

Unidentified side-effects:

  • There are no scientific tests offered on the short and also long term results of using these products or if the doses suggested by suppliers are secure.
  • There is no test information readily available on how these products may interact with various other drugs or their result on a coming kid.

Injecting devices

  • Needles used to inject can likewise lug physical fluids, which can hand down infections such as HIV and also liver disease. In many cases, there is an undersupply of needles by the online vendors for the amount of administration needed, e.g. 1 needle provided with a 10 dose vial.
  • This can result in sharing and recycling of needles. There are reports of customers utilizing the exact same needle for a month and attempting to sterilise after every usage.
  • A multi-dose vial manufactured in a non-rigorous manufacturing environment may not continue to be sterilized for the duration of its use e.g. a 30mg vial is made to be utilized for 30 dosages which might cover an amount of time of 10 weeks.
  • Some websites supply pre-filled syringes in which the product is currently re-constituted with bacteriostatic water, nevertheless there is no warranty that these pre-filled products will certainly stay stable and sterilized during distribution or for the lifetime of their use.

Disposal of used sharps

There have been records of needles being taken care of in household rubbish.

Enhanced exposure to UV rays

As the results of the tanning representatives are much more remarkable when utilized combined with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the representatives might enhance UV direct exposure with all the enhancement threats linked such as increased risk of skin cancer cells, skin ageing, and so on

Harm reduction actions

  • Clarify to users about the dangers connected with injectable tanning products.
  • Highlight the risks connected with enhanced UV exposure (the sick results of tanning still occur even in customers that have a deep tan). Clients can get in touch with the Irish Cancer Culture if they have worries regarding skin cancer cells on the cancer helpline 1800 200 700 or
  • Motivate individuals to quit using, and also to seek medical advice if required.

If utilizing

Clean infusing equipment:

  • Advise that they make use of a tidy needle every single time as well as deal with needles in a sharps container. The needles readily available in the infusing pack offered in pharmacies joining the Pharmacy Needle Exchange Program are created like a diabetic needle and also are suitable for subcutaneous injection.
  • Encourage clients on the danger of blood birthed illness as well as supply advice on whom to call if the client is worried that they may have revealed themselves to a blood borne disease by sharing needles.
  • A checklist of drug stores participating in your location is available through the Medications helpline 1800 459 459.

Safe disposal.

The pack also has a small sharps container for made use of sharps. Drug stores will accept made use of sharps if returned in the sharps container.

Pollutant and instability of product.

  • The quantity of item in the vial may vary considerably, might be infected with germs or various other chemicals.
  • Inspect the vial before use and also do not make use of if stained or if bits visible.
  • It has to be saved in the fridge.
  • All drugs need to be kept out of the reach of kids which may be hard in a refrigerator.


  • Advise that side-effects are unidentified, and the dosages being made use of might not be risk-free.
  • Impacts of the drug on a coming kid are unknown.
  • Results when taken with other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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