Does Melanotan need to be cooled?

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When you tan your entire body, you’re subjecting all your skin to harmful UV rays. If your skin frequently gets subjected to UV rays way too much, it’ll trigger wellness concerns and also skin concerns for you.

Thankfully, Melanotan peptide can assist you deal with these tanning concerns by permitting your body to boost its manufacturing of melanin. Whenever your body experiences UV damage, it naturally responds by generating melanin. This is a peptide hormone which normally darkens the skin in order to secure it from the destructive UV rays.


Advice on the usage on injecting tanning representatives, e.g. Melanotan


Due to the current attention and warnings regarding the risks of infusing melanotan the HSE has actually released info and also suggestions on the use on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was established by the College of Arizona in 1981 to be utilized for picture protection versus sun damage. This medication is presently undergoing scientific tests for use in patients with details sun-sensitive skin disease as well as is not available for basic sale.

The medication is chemically connected to the alpha-melanocyte stimulating hormonal agent (α-MSH) as well as binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital duty in figuring out skin and also hair pigmentation, raises production of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH and is unlawful, untested and also uncontrolled which is currently being sold online for self-administration. α-MSH is really breakable and needs a rigorous manufacturing setting which can not be guaranteed in unlicensed manufacturing laboratories. The product has to additionally be kept in a fridge.

What is the distinction between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning therefore has much less negative effects. Nevertheless much more of it is needed for effect and as a result it is more pricey than Melanotan II.

Melanotan II binds to receptors other than those in charge of tanning and therefore causes even more side-effects.

What are the side-effects?

As this is an unregulated and untried drug the full series of prospective side-effects are unidentified. Boosted libido, spontaneous erections, nausea (with succeeding weight management), facial flushing on administration, flu-like signs, and also enhanced high blood pressure have actually been reported.

Just how is Melanotan provided?

Melanotan is carried out subcutaneously by infusing right into the fatty layer of cells around the stomach button area. Clients infuse daily till a wanted colour is attained and then continue to inject one or two times a week to keep the colour.

Some darkening of the skin might happen using the injection alone however the effects are even more remarkable when made use of in addition to exposure to UV light (sunlight or tanning bed) 2-3 times a week initially and afterwards 1-2 times a week after that.

Just how is Melanotan offered?

Products on the marketplace consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A collection of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Key issues

Item purity and material:

  • This is an unlicensed, unregulated product. This is a breakable medicine which requires refrigeration.
  • Customers may reluctant to place the item in their family members refrigerator. If pre-filled syringes are positioned in the fridge this has effects in regards to accessibility of children to syringes.

Unknown side-effects:

  • There are no scientific trials available on the brief and also long term results of using these products or if the doses recommended by manufacturers are safe.
  • There is no trial data available on exactly how these products may engage with other drugs or their effect on an unborn child.

Injecting tools

  • Needles utilized to infuse might likewise carry physical fluids, which can hand down infections such as HIV and liver disease. In some cases, there is an undersupply of needles by the on-line vendors for the amount of administration needed, e.g. 1 needle supplied with a 10 dosage vial.
  • This can lead to sharing and reusing of needles. There are reports of clients utilizing the same needle for a month as well as trying to sterilise after every usage.
  • A multi-dose vial produced in a non-rigorous manufacturing setting might not continue to be sterilized throughout of its use e.g. a 30mg vial is designed to be made use of for 30 doses which may span a time period of 10 weeks.
  • Some sites offer pre-filled syringes in which the item is already re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled items will stay secure and sterile during delivery or for the lifetime of their use.

Disposal of used sharps

There have actually been reports of needles being thrown away in household rubbish.

Enhanced direct exposure to UV rays

As the results of the tanning representatives are a lot more significant when made use of in conjunction with direct exposure to UV light (by natural sunshine or by tanning beds) use of the representatives may raise UV direct exposure with all the addition risks associated such as enhanced threat of skin cancer cells, skin ageing, etc

Harm decrease activities

  • Discuss to users regarding the dangers related to injectable tanning products.
  • Highlight the risks connected with raised UV direct exposure (the unwell impacts of tanning still occur also in customers who have a deep tan). Customers can contact the Irish Cancer Society if they have problems concerning skin cancer cells on the cancer helpline 1800 200 700 or
  • Encourage users to quit using, and to seek clinical suggestions if needed.

If using

Clean infusing equipment:

  • Suggest that they utilize a tidy needle every time as well as deal with needles in a sharps container. The needles offered in the injecting pack available in pharmacies participating in the Drug store Needle Exchange Program are made like a diabetic person needle as well as are suitable for subcutaneous injection.
  • Advise customers on the risk of blood birthed illness as well as offer recommendations on whom to call if the customer is concerned that they may have subjected themselves to a blood borne disease by sharing needles.
  • A checklist of pharmacies taking part in your location is readily available through the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally includes a small sharps container for made use of sharps. Drug stores will approve utilized sharps if returned in the sharps container.

Impurity as well as instability of item.

  • The amount of product in the vial might differ significantly, might be contaminated with microorganisms or various other chemicals.
  • Inspect the vial prior to usage as well as do not make use of if blemished or if bits noticeable.
  • It needs to be saved in the fridge.
  • All medicines must be kept out of the reach of children which might be challenging in a fridge.


  • Recommend that side-effects are unknown, as well as the doses being used might not be risk-free.
  • Effects of the medication on an unborn youngster are unidentified.
  • Results when taken with various other medications are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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