Does Melanotan require to be refrigerated?

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Recommendations on the use on infusing tanning agents, e.g. Melanotan


Because of the current publicity and also warnings concerning the threats of injecting melanotan the HSE has actually launched information and also advice on the usage on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was established by the College of Arizona in 1981 to be utilized for photo defense against sun damages. This drug is currently undergoing scientific tests for usage in people with specific sun-sensitive skin disease as well as is not offered for general sale.

The medication is chemically associated with the alpha-melanocyte stimulating hormone (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential function in identifying skin as well as hair coloring, increases manufacturing of melanin in the skin, causing a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH and also is illegal, untested and also unregulated which is presently being offered online for self-administration. α-MSH is very delicate and needs a strenuous manufacturing atmosphere which can not be ensured in unlicensed production research laboratories. The item should likewise be kept in a refrigerator.

What is the distinction in between Melanotan I as well as Melanotan II?

Melanotan I especially binds to receptors responsible for tanning and so has less adverse effects. Nonetheless a lot more of it is needed for result as well as consequently it is more pricey than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning and consequently results in even more side-effects.

What are the side-effects?

As this is an uncontrolled and untested drug the full variety of prospective side-effects are unidentified. Boosted libido, spontaneous erections, queasiness (with succeeding weight reduction), face flushing on management, flu-like signs, and also increased high blood pressure have actually been reported.

Exactly how is Melanotan administered?

Melanotan is provided subcutaneously by injecting right into the fatty layer of tissue around the stomach switch location. Clients inject daily till a preferred colour is attained and then continue to inject one or two times a week to keep the colour.

Some darkening of the skin may happen using the injection alone however the impacts are far more remarkable when made use of along with exposure to UV light (sun or tanning bed) 2-3 times a week originally and afterwards 1-2 times a week after that.

Exactly how is Melanotan readily available?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main issues

Product pureness as well as web content:

  • This is an unlicensed, uncontrolled item. This is a breakable medicine which requires refrigeration.
  • Customers may reluctant to put the product in their family members refrigerator. If pre-filled syringes are placed in the fridge this has effects in terms of accessibility of children to syringes.

Unknown side-effects:

  • There are no clinical trials readily available on the short as well as long term results of using these products or if the doses advised by producers are safe.
  • There is no test data readily available on just how these products may connect with various other drugs or their result on an expected youngster.

Injecting devices

  • Needles utilized to inject could likewise carry bodily liquids, which can hand down infections such as HIV and also hepatitis. In many cases, there is an undersupply of needles by the online vendors for the quantity of management required, e.g. 1 needle provided with a 10 dose vial.
  • This might lead to sharing and recycling of needles. There are records of clients utilizing the same needle for a month as well as trying to sterilise after every usage.
  • A multi-dose vial manufactured in a non-rigorous production atmosphere might not continue to be sterile throughout of its usage e.g. a 30mg vial is made to be made use of for 30 doses which might cover a time period of 10 weeks.
  • Some websites use pre-filled syringes in which the item is already re-constituted with bacteriostatic water, however there is no guarantee that these pre-filled items will certainly continue to be secure as well as sterile during delivery or for the lifetime of their usage.

Disposal of used sharps

There have actually been records of needles being thrown away in home rubbish.

Enhanced direct exposure to UV rays

As the impacts of the tanning agents are a lot more significant when utilized combined with exposure to UV light (by all-natural sunlight or by tanning beds) use of the representatives may enhance UV exposure with all the enhancement threats associated such as boosted risk of skin cancer, skin ageing, etc

Damage reduction activities

  • Discuss to individuals regarding the threats connected with injectable tanning items.
  • Highlight the risks related to enhanced UV exposure (the sick results of tanning still happen also in customers who have a deep tan). Customers can call the Irish Cancer Society if they have problems relating to skin cancer on the cancer helpline 1800 200 700 or
  • Encourage customers to quit using, and also to seek clinical suggestions if needed.

If making use of

Tidy infusing tools:

  • Encourage that they utilize a clean needle each time and dispose of needles in a sharps container. The needles readily available in the infusing pack available in pharmacies joining the Pharmacy Needle Exchange Program are created like a diabetic person needle and also are suitable for subcutaneous shot.
  • Encourage customers on the risk of blood borne conditions and also provide suggestions on whom to contact if the customer is concerned that they may have revealed themselves to a blood birthed disease by sharing needles.
  • A list of pharmacies taking part in your location is available via the Drugs helpline 1800 459 459.

Safe disposal.

The pack also contains a little sharps container for made use of sharps. Pharmacies will accept utilized sharps if returned in the sharps container.

Impurity and also instability of item.

  • The amount of item in the vial may vary considerably, might be infected with microorganisms or other chemicals.
  • Examine the vial prior to usage and also do not utilize if discolored or if particles visible.
  • It should be stored in the refrigerator.
  • All drugs should be shut out of the reach of kids which might be challenging in a refrigerator.


  • Advise that side-effects are unknown, and also the doses being utilized might not be secure.
  • Results of the medication on an expected child are unknown.
  • Effects when taken with other drugs are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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