Does Melanotan work without sunlight? – 2021


When you tan your whole body, you’re subjecting all your skin to dangerous UV rays. If your skin on a regular basis gets revealed to UV rays too much, it’ll trigger wellness concerns and also skin problems for you.

The good news is, Melanotan peptide can assist you deal with these tanning concerns by enabling your body to boost its manufacturing of melanin. Whenever your body experiences UV damages, it naturally responds by producing melanin. This is a peptide hormone which normally dims the skin in order to protect it from the destructive UV rays.


Suggestions on the usage on infusing tanning representatives, e.g. Melanotan


As a result of the recent attention and also warnings regarding the dangers of injecting melanotan the HSE has released information and also suggestions on the usage on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medication (afamelanotide) which was established by the College of Arizona in 1981 to be used for picture defense versus sunlight damages. This drug is currently undergoing professional trials for usage in patients with certain sun-sensitive skin problem as well as is not available for general sale.

The drug is chemically related to the alpha-melanocyte stimulating hormone (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital role in identifying skin as well as hair pigmentation, enhances manufacturing of melanin in the skin, causing a ‘sun tan’.

Melanotan is an artificial analog of α-MSH and is illegal, untried as well as unregulated which is presently being marketed online for self-administration. α-MSH is extremely delicate as well as calls for an extensive production setting which can not be assured in unlicensed manufacturing laboratories. The product needs to likewise be kept in a fridge.

What is the difference in between Melanotan I as well as Melanotan II?

Melanotan I particularly binds to receptors in charge of tanning and so has much less side effects. However a lot more of it is needed for result and as a result it is extra pricey than Melanotan II.

Melanotan II binds to receptors apart from those in charge of tanning as well as therefore causes even more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untried medicine the complete series of potential side-effects are unidentified. Enhanced libido, spontaneous erections, queasiness (with succeeding weight loss), facial flushing on management, flu-like signs and symptoms, and also raised high blood pressure have actually been reported.

Exactly how is Melanotan carried out?

Melanotan is provided subcutaneously by injecting into the fatty layer of tissue around the belly button location. Clients inject daily till a preferred colour is achieved and afterwards remain to inject once or twice a week to preserve the colour.

Some darkening of the skin may take place making use of the shot alone however the effects are much more remarkable when used together with exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and after that 1-2 times a week after that.

Just how is Melanotan readily available?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Key concerns

Item pureness as well as content:

  • This is an unlicensed, unregulated product. This is a delicate drug which needs refrigeration.
  • Individuals might unwilling to put the product in their household fridge. If pre-filled syringes are put in the refrigerator this has implications in terms of accessibility of kids to syringes.

Unknown side-effects:

  • There are no clinical tests readily available on the short and also long-term impacts of using these products or if the doses advised by manufacturers are risk-free.
  • There is no trial data readily available on just how these products may communicate with other medications or their effect on an unborn child.

Infusing devices

  • Needles utilized to infuse might also lug physical fluids, which can pass on infections such as HIV and also hepatitis. In many cases, there is an undersupply of needles by the on-line suppliers for the quantity of management called for, e.g. 1 needle provided with a 10 dose vial.
  • This might result in sharing and recycling of needles. There are records of clients utilizing the exact same needle for a month and also attempting to sterilise after every usage.
  • A multi-dose vial produced in a non-rigorous manufacturing setting might not stay sterilized throughout of its usage e.g. a 30mg vial is created to be utilized for 30 doses which might span a period of 10 weeks.
  • Some websites supply pre-filled syringes in which the product is already re-constituted with bacteriostatic water, however there is no guarantee that these pre-filled items will certainly continue to be secure as well as clean and sterile during distribution or for the lifetime of their usage.

Disposal of used sharps

There have actually been records of needles being taken care of in home rubbish.

Raised direct exposure to UV rays

As the effects of the tanning agents are a lot more significant when utilized together with exposure to UV light (by natural sunlight or by tanning beds) use the representatives may boost UV exposure with all the addition dangers connected such as raised risk of skin cancer, skin ageing, etc

Harm decrease activities

  • Clarify to individuals concerning the dangers associated with injectable tanning items.
  • Highlight the risks related to raised UV direct exposure (the unwell results of tanning still happen also in customers that have a deep tan). Customers can get in touch with the Irish Cancer Society if they have concerns pertaining to skin cancer on the cancer helpline 1800 200 700 or
  • Motivate individuals to stop utilizing, as well as to seek clinical suggestions if needed.

If making use of

Clean injecting tools:

  • Recommend that they use a clean needle whenever and throw away needles in a sharps container. The needles readily available in the injecting pack available in pharmacies joining the Pharmacy Needle Exchange Program are developed like a diabetic person needle as well as appropriate for subcutaneous shot.
  • Encourage clients on the danger of blood borne diseases and also provide guidance on whom to call if the customer is worried that they might have exposed themselves to a blood birthed condition by sharing needles.
  • A checklist of drug stores taking part in your location is offered via the Medicines helpline 1800 459 459.

Safe disposal.

The pack likewise consists of a small sharps container for made use of sharps. Pharmacies will accept utilized sharps if returned in the sharps container.

Impurity and also instability of product.

  • The quantity of item in the vial might differ considerably, may be contaminated with microorganisms or various other chemicals.
  • Examine the vial prior to usage as well as do not make use of if stained or if fragments noticeable.
  • It needs to be saved in the refrigerator.
  • All drugs should be shut out of the reach of youngsters which might be hard in a refrigerator.


  • Recommend that side-effects are unknown, as well as the doses being made use of might not be secure.
  • Impacts of the medicine on a coming kid are unknown.
  • Results when taken with other drugs are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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