Exactly how poor is Melanotan? – 2021


When you tan your whole body, you’re revealing all your skin to dangerous UV rays. If your skin routinely obtains revealed to UV rays way too much, it’ll cause health and wellness concerns and skin problems for you.

The good news is, Melanotan peptide can aid you deal with these tanning issues by allowing your body to enhance its production of melanin. Whenever your body suffers UV damages, it normally reacts by creating melanin. This is a peptide hormone which normally dims the skin in order to secure it from the damaging UV rays.


Guidance on the usage on injecting tanning agents, e.g. Melanotan


As a result of the recent promotion and also warnings concerning the threats of infusing melanotan the HSE has actually launched info as well as guidance on the usage on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was developed by the College of Arizona in 1981 to be made use of for picture defense against sun damages. This drug is presently undertaking scientific tests for usage in clients with specific sun-sensitive skin disease and is not readily available for general sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital function in figuring out skin and hair pigmentation, boosts manufacturing of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH and is unlawful, untried as well as unregulated which is presently being offered online for self-administration. α-MSH is extremely delicate and requires an extensive manufacturing setting which can not be assured in unlicensed production laboratories. The item has to likewise be stored in a refrigerator.

What is the difference in between Melanotan I as well as Melanotan II?

Melanotan I especially binds to receptors in charge of tanning and so has less side effects. Nonetheless a lot more of it is required for impact and also for that reason it is more costly than Melanotan II.

Melanotan II binds to receptors other than those responsible for tanning as well as as a result results in even more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untried medication the full series of potential side-effects are unidentified. Increased sex drive, spontaneous erections, nausea or vomiting (with succeeding weight management), facial flushing on administration, flu-like signs and symptoms, and also increased high blood pressure have been reported.

How is Melanotan provided?

Melanotan is administered subcutaneously by infusing right into the fatty layer of tissue around the stomach button area. Customers infuse daily up until a wanted colour is attained and after that remain to inject one or two times a week to maintain the colour.

Some darkening of the skin might occur using the shot alone yet the results are even more significant when made use of together with exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and then 1-2 times a week thereafter.

How is Melanotan readily available?

Products on the market include:

  • A multi- dosage vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key worries

Item pureness as well as material:

  • This is an unlicensed, unregulated item. This is a fragile medication which requires refrigeration.
  • Individuals may reluctant to position the item in their family members fridge. If pre-filled syringes are put in the fridge this has ramifications in regards to gain access to of kids to syringes.

Unidentified side-effects:

  • There are no medical tests available on the short and also long term results of using these items or if the dosages suggested by manufacturers are safe.
  • There is no test information available on exactly how these items may connect with other medicines or their impact on a coming youngster.

Injecting devices

  • Needles utilized to infuse might additionally lug physical fluids, which can hand down infections such as HIV and also hepatitis. In some cases, there is an undersupply of needles by the on-line suppliers for the quantity of management needed, e.g. 1 needle supplied with a 10 dose vial.
  • This can lead to sharing and recycling of needles. There are records of clients making use of the same needle for a month and trying to sterilise after every use.
  • A multi-dose vial manufactured in a non-rigorous production atmosphere might not stay sterilized for the duration of its usage e.g. a 30mg vial is created to be made use of for 30 doses which might span a period of 10 weeks.
  • Some sites offer pre-filled syringes in which the item is already re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled products will certainly remain stable and also sterilized during delivery or for the lifetime of their use.

Disposal of used sharps

There have been records of needles being dealt with in house rubbish.

Increased direct exposure to UV rays

As the effects of the tanning agents are a lot more significant when used combined with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the agents may raise UV exposure with all the enhancement dangers associated such as increased danger of skin cancer cells, skin ageing, and so on

Harm reduction actions

  • Explain to users regarding the threats connected with injectable tanning items.
  • Highlight the dangers related to boosted UV direct exposure (the unwell effects of sun tanning still take place also in customers that have a deep tan). Customers can speak to the Irish Cancer cells Culture if they have problems concerning skin cancer cells on the cancer helpline 1800 200 700 or www.cancer.ie
  • Urge individuals to quit utilizing, and also to look for medical advice if needed.

If making use of

Clean injecting devices:

  • Recommend that they use a clean needle each time and also take care of needles in a sharps container. The needles available in the injecting pack readily available in drug stores participating in the Drug store Needle Exchange Program are developed like a diabetic person needle as well as appropriate for subcutaneous shot.
  • Suggest customers on the risk of blood birthed conditions and provide suggestions on whom to speak to if the client is worried that they might have subjected themselves to a blood birthed disease by sharing needles.
  • A list of drug stores participating in your area is available via the Medications helpline 1800 459 459.

Safe disposal.

The pack additionally has a little sharps container for utilized sharps. Pharmacies will certainly approve used sharps if returned in the sharps container.

Contamination and instability of item.

  • The amount of product in the vial might differ substantially, may be polluted with bacteria or other chemicals.
  • Examine the vial prior to usage and also do not make use of if stained or if bits noticeable.
  • It needs to be stored in the refrigerator.
  • All medications ought to be kept out of the reach of kids which might be difficult in a fridge.


  • Recommend that side-effects are unknown, and the doses being used might not be risk-free.
  • Effects of the drug on an unborn child are unidentified.
  • Effects when taken with various other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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