How do you administer Melanotan? – 2021

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Advice on the use on infusing tanning representatives, e.g. Melanotan


Due to the current promotion as well as warnings concerning the dangers of infusing melanotan the HSE has launched info and suggestions on the usage on injecting tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was created by the College of Arizona in 1981 to be made use of for picture security versus sun damages. This drug is currently going through scientific trials for usage in individuals with certain sun-sensitive skin problem and is not offered for basic sale.

The medication is chemically connected to the alpha-melanocyte stimulating hormone (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key function in figuring out skin and hair coloring, raises production of melanin in the skin, causing a ‘sun tan’.

Melanotan is a synthetic analog of α-MSH as well as is illegal, untested as well as uncontrolled which is currently being offered online for self-administration. α-MSH is very breakable as well as needs a rigorous manufacturing setting which can not be ensured in unlicensed production research laboratories. The product needs to likewise be kept in a fridge.

What is the difference in between Melanotan I and Melanotan II?

Melanotan I particularly binds to receptors responsible for tanning and so has less side effects. Nonetheless far more of it is required for effect and also for that reason it is extra pricey than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning and also as a result results in even more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untested medication the full series of prospective side-effects are unknown. Raised sex drive, spontaneous erections, nausea or vomiting (with subsequent weight-loss), facial flushing on management, flu-like signs, and raised blood pressure have been reported.

Just how is Melanotan carried out?

Melanotan is administered subcutaneously by injecting into the fatty layer of cells around the stomach button location. Clients inject daily till a wanted colour is attained and after that continue to infuse one or two times a week to maintain the colour.

Some dimming of the skin might take place using the shot alone but the effects are much more significant when utilized in addition to exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week thereafter.

How is Melanotan offered?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A collection of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main problems

Item pureness and content:

  • This is an unlicensed, unregulated product. This is a breakable medicine which needs refrigeration.
  • Individuals might hesitant to position the product in their household refrigerator. If pre-filled syringes are placed in the refrigerator this has effects in terms of access of children to syringes.

Unknown side-effects:

  • There are no clinical tests available on the brief and long-term results of using these items or if the doses advised by suppliers are secure.
  • There is no test data readily available on how these items might communicate with other drugs or their impact on a coming child.

Infusing tools

  • Needles used to infuse could additionally lug physical fluids, which can hand down infections such as HIV and liver disease. In many cases, there is an undersupply of needles by the on-line vendors for the amount of management required, e.g. 1 needle supplied with a 10 dosage vial.
  • This might bring about sharing and reusing of needles. There are records of clients using the same needle for a month as well as attempting to sterilise after every use.
  • A multi-dose vial manufactured in a non-rigorous manufacturing atmosphere may not remain clean and sterile throughout of its use e.g. a 30mg vial is made to be made use of for 30 doses which may cover a period of 10 weeks.
  • Some websites provide pre-filled syringes in which the item is currently re-constituted with bacteriostatic water, nonetheless there is no guarantee that these pre-filled products will stay secure and sterile throughout delivery or for the life expectancy of their usage.

Disposal of used sharps

There have actually been reports of needles being taken care of in home rubbish.

Increased exposure to UV rays

As the impacts of the tanning agents are much more remarkable when utilized combined with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the representatives may enhance UV exposure with all the enhancement dangers linked such as enhanced danger of skin cancer cells, skin ageing, etc

Damage reduction activities

  • Explain to customers concerning the threats associated with injectable tanning products.
  • Highlight the threats connected with boosted UV direct exposure (the unwell effects of sun tanning still happen also in customers who have a deep tan). Clients can call the Irish Cancer cells Culture if they have worries regarding skin cancer on the cancer helpline 1800 200 700 or
  • Urge individuals to stop making use of, and also to seek clinical advice if needed.

If making use of

Tidy infusing devices:

  • Suggest that they make use of a clean needle each time and also throw away needles in a sharps container. The needles offered in the infusing pack readily available in pharmacies participating in the Pharmacy Needle Exchange Program are created like a diabetic person needle and are suitable for subcutaneous injection.
  • Suggest customers on the threat of blood birthed conditions and also supply guidance on whom to call if the client is concerned that they might have revealed themselves to a blood borne disease by sharing needles.
  • A checklist of drug stores participating in your area is available through the Drugs helpline 1800 459 459.

Safe disposal.

The pack likewise contains a tiny sharps container for used sharps. Drug stores will accept utilized sharps if returned in the sharps container.

Contamination and instability of product.

  • The amount of product in the vial may vary considerably, may be polluted with bacteria or various other chemicals.
  • Inspect the vial before use and also do not utilize if blemished or if fragments visible.
  • It needs to be saved in the refrigerator.
  • All medications ought to be kept out of the reach of children which may be difficult in a fridge.


  • Advise that side-effects are unknown, and the dosages being made use of might not be secure.
  • Effects of the medicine on an unborn kid are unidentified.
  • Impacts when taken with other drugs are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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