How much Melanotan 2 do I inject? – 2021

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Advice on the usage on injecting tanning representatives, e.g. Melanotan


As a result of the current attention as well as warnings regarding the dangers of injecting melanotan the HSE has actually released information and also advice on the usage on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was developed by the College of Arizona in 1981 to be utilized for photo security versus sunlight damages. This drug is currently going through clinical tests for use in patients with details sun-sensitive skin problem and is not offered for general sale.

The medication is chemically associated with the alpha-melanocyte stimulating hormonal agent (α-MSH) as well as binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key function in figuring out skin and also hair coloring, raises production of melanin in the skin, resulting in a ‘sun tan’.

Melanotan is a synthetic analog of α-MSH and is unlawful, untried and unregulated which is presently being offered online for self-administration. α-MSH is very vulnerable and also calls for a strenuous production environment which can not be guaranteed in unlicensed production laboratories. The item needs to likewise be saved in a fridge.

What is the distinction between Melanotan I and Melanotan II?

Melanotan I especially binds to receptors in charge of tanning therefore has less negative effects. Nevertheless a lot more of it is needed for impact as well as therefore it is extra pricey than Melanotan II.

Melanotan II binds to receptors aside from those in charge of tanning and also as a result causes even more side-effects.

What are the side-effects?

As this is an uncontrolled and also untested medicine the full range of potential side-effects are unidentified. Increased libido, spontaneous erections, nausea or vomiting (with succeeding weight loss), facial flushing on administration, flu-like signs and symptoms, and enhanced high blood pressure have actually been reported.

Just how is Melanotan administered?

Melanotan is administered subcutaneously by infusing into the fatty layer of tissue around the tummy button area. Clients infuse daily till a preferred colour is attained and after that remain to inject one or two times a week to keep the colour.

Some darkening of the skin may occur utilizing the injection alone yet the results are even more significant when utilized in addition to direct exposure to UV light (sun or tanning bed) 2-3 times a week originally and then 1-2 times a week after that.

How is Melanotan available?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A collection of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Key worries

Product pureness and also content:

  • This is an unlicensed, uncontrolled product. This is a breakable medication which requires refrigeration.
  • Users might hesitant to put the product in their household fridge. If pre-filled syringes are put in the fridge this has implications in terms of access of children to syringes.

Unknown side-effects:

  • There are no medical tests available on the brief as well as long-term results of using these items or if the dosages recommended by producers are risk-free.
  • There is no test information available on exactly how these products might engage with various other medicines or their effect on an unborn child.

Injecting tools

  • Needles used to infuse could additionally carry physical liquids, which can hand down infections such as HIV and hepatitis. Sometimes, there is an undersupply of needles by the on the internet suppliers for the amount of management required, e.g. 1 needle provided with a 10 dosage vial.
  • This can result in sharing and recycling of needles. There are records of clients utilizing the exact same needle for a month and also trying to sterilise after every use.
  • A multi-dose vial made in a non-rigorous manufacturing atmosphere might not stay sterilized for the duration of its usage e.g. a 30mg vial is developed to be made use of for 30 doses which might span a time period of 10 weeks.
  • Some websites offer pre-filled syringes in which the product is currently re-constituted with bacteriostatic water, however there is no warranty that these pre-filled items will remain secure as well as sterilized during distribution or for the life expectancy of their use.

Disposal of used sharps

There have been records of needles being taken care of in household rubbish.

Increased direct exposure to UV rays

As the impacts of the tanning agents are much more remarkable when used in conjunction with exposure to UV light (by natural sunshine or by tanning beds) use the agents might boost UV direct exposure with all the addition dangers linked such as boosted threat of skin cancer cells, skin ageing, etc

Injury decrease actions

  • Describe to individuals regarding the threats connected with injectable tanning items.
  • Highlight the threats related to raised UV direct exposure (the ill results of tanning still happen even in clients that have a deep tan). Customers can contact the Irish Cancer cells Culture if they have problems pertaining to skin cancer cells on the cancer helpline 1800 200 700 or
  • Motivate users to quit making use of, and also to seek medical advice if required.

If utilizing

Clean injecting devices:

  • Suggest that they use a tidy needle each time and also get rid of needles in a sharps container. The needles readily available in the injecting pack readily available in pharmacies joining the Pharmacy Needle Exchange Program are created like a diabetic needle and also appropriate for subcutaneous injection.
  • Recommend customers on the danger of blood birthed illness and provide recommendations on whom to speak to if the client is worried that they might have exposed themselves to a blood borne disease by sharing needles.
  • A checklist of drug stores participating in your area is available with the Medicines helpline 1800 459 459.

Safe disposal.

The pack also has a small sharps container for made use of sharps. Pharmacies will approve made use of sharps if returned in the sharps container.

Impurity and also instability of item.

  • The amount of item in the vial might differ significantly, might be contaminated with bacteria or various other chemicals.
  • Inspect the vial before use and do not make use of if blemished or if fragments noticeable.
  • It has to be kept in the fridge.
  • All drugs should be kept out of the reach of children which may be hard in a refrigerator.


  • Recommend that side-effects are unidentified, and also the doses being made use of may not be safe.
  • Impacts of the medicine on an expected child are unknown.
  • Effects when taken with other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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