How negative is Melanotan? – 2021

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Suggestions on the usage on infusing tanning representatives, e.g. Melanotan


Due to the current attention as well as cautions concerning the dangers of injecting melanotan the HSE has launched information and also advice on the usage on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medication (afamelanotide) which was developed by the College of Arizona in 1981 to be made use of for photo security versus sun damages. This drug is currently undertaking clinical trials for use in individuals with details sun-sensitive skin disease and also is not available for basic sale.

The drug is chemically connected to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential function in determining skin and also hair coloring, boosts manufacturing of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is a synthetic analog of α-MSH and also is prohibited, untested and also uncontrolled which is currently being sold online for self-administration. α-MSH is extremely delicate and needs a rigorous manufacturing environment which can not be guaranteed in unlicensed manufacturing laboratories. The product should also be saved in a refrigerator.

What is the distinction between Melanotan I and also Melanotan II?

Melanotan I specifically binds to receptors responsible for tanning and so has much less adverse effects. However a lot more of it is needed for effect as well as therefore it is more expensive than Melanotan II.

Melanotan II binds to receptors other than those in charge of tanning and consequently causes even more side-effects.

What are the side-effects?

As this is an unregulated and untried drug the complete series of potential side-effects are unidentified. Boosted sex drive, spontaneous erections, queasiness (with subsequent weight-loss), face flushing on management, flu-like signs and symptoms, as well as boosted high blood pressure have been reported.

Just how is Melanotan administered?

Melanotan is administered subcutaneously by injecting into the fatty layer of tissue around the tummy switch area. Clients infuse daily until a preferred colour is accomplished and after that remain to infuse one or two times a week to preserve the colour.

Some darkening of the skin might take place using the shot alone yet the impacts are far more significant when made use of together with exposure to UV light (sunlight or tanning bed) 2-3 times a week initially and after that 1-2 times a week thereafter.

Just how is Melanotan available?

Products on the market include:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key concerns

Product pureness as well as material:

  • This is an unlicensed, uncontrolled product. This is a vulnerable medicine which needs refrigeration.
  • Individuals may reluctant to position the item in their household refrigerator. If pre-filled syringes are placed in the refrigerator this has ramifications in regards to gain access to of youngsters to syringes.

Unidentified side-effects:

  • There are no professional trials offered on the short as well as long term impacts of using these items or if the doses recommended by producers are risk-free.
  • There is no test data offered on exactly how these items may connect with other medicines or their impact on an expected kid.

Infusing devices

  • Needles utilized to inject could additionally lug bodily liquids, which can hand down infections such as HIV as well as hepatitis. In many cases, there is an undersupply of needles by the on-line vendors for the amount of management needed, e.g. 1 needle supplied with a 10 dosage vial.
  • This can bring about sharing and also recycling of needles. There are records of customers making use of the exact same needle for a month and trying to sterilise after every usage.
  • A multi-dose vial produced in a non-rigorous production environment may not continue to be clean and sterile for the duration of its usage e.g. a 30mg vial is developed to be used for 30 doses which might cover an amount of time of 10 weeks.
  • Some websites supply pre-filled syringes in which the item is already re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled items will certainly remain steady as well as sterilized throughout distribution or for the lifetime of their usage.

Disposal of used sharps

There have actually been records of needles being thrown away in house rubbish.

Increased exposure to UV rays

As the results of the tanning representatives are extra significant when made use of combined with direct exposure to UV light (by all-natural sunlight or by tanning beds) use of the agents may enhance UV direct exposure with all the enhancement threats associated such as enhanced danger of skin cancer, skin ageing, etc

Injury decrease actions

  • Describe to individuals about the risks connected with injectable tanning products.
  • Highlight the dangers connected with increased UV direct exposure (the sick effects of sun tanning still happen even in customers who have a deep tan). Customers can speak to the Irish Cancer Culture if they have worries relating to skin cancer cells on the cancer helpline 1800 200 700 or
  • Urge users to quit using, and to look for medical guidance if needed.

If making use of

Clean injecting tools:

  • Recommend that they make use of a clean needle every single time as well as take care of needles in a sharps container. The needles available in the injecting pack available in pharmacies participating in the Drug store Needle Exchange Program are designed like a diabetic person needle and appropriate for subcutaneous injection.
  • Encourage customers on the risk of blood birthed diseases and also use advice on whom to contact if the client is worried that they may have subjected themselves to a blood birthed disease by sharing needles.
  • A listing of drug stores joining your area is readily available through the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally has a small sharps container for utilized sharps. Drug stores will certainly accept utilized sharps if returned in the sharps container.

Contamination as well as instability of product.

  • The quantity of product in the vial may vary substantially, might be contaminated with microorganisms or various other chemicals.
  • Examine the vial prior to use and do not use if tarnished or if particles noticeable.
  • It must be stored in the fridge.
  • All medicines should be shut out of the reach of kids which may be tough in a fridge.


  • Advise that side-effects are unidentified, as well as the doses being made use of might not be risk-free.
  • Results of the medication on a coming kid are unidentified.
  • Results when taken with other medicines are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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