Is Melanotan 2 irreversible? – 2021

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When you tan your entire body, you’re exposing all your skin to harmful UV rays. If your skin routinely gets revealed to UV rays way too much, it’ll create wellness concerns and also skin problems for you.

The good news is, Melanotan peptide can aid you handle these tanning issues by enabling your body to raise its manufacturing of melanin. Whenever your body experiences UV damage, it naturally reacts by generating melanin. This is a peptide hormonal agent which naturally dims the skin in order to secure it from the destructive UV rays.


Recommendations on the use on infusing tanning agents, e.g. Melanotan


As a result of the recent attention as well as warnings regarding the threats of injecting melanotan the HSE has launched info as well as guidance on the use on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medicine (afamelanotide) which was created by the University of Arizona in 1981 to be used for image security against sunlight damages. This medicine is currently undergoing medical trials for use in clients with specific sun-sensitive skin disease and also is not readily available for basic sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a crucial duty in establishing skin as well as hair coloring, enhances manufacturing of melanin in the skin, causing a ‘sun tan’.

Melanotan is a synthetic analog of α-MSH and also is unlawful, untested as well as uncontrolled which is presently being offered online for self-administration. α-MSH is really breakable and requires a rigorous production atmosphere which can not be guaranteed in unlicensed manufacturing research laboratories. The item needs to additionally be saved in a fridge.

What is the difference between Melanotan I and Melanotan II?

Melanotan I particularly binds to receptors in charge of tanning therefore has much less adverse effects. Nevertheless much more of it is needed for result and for that reason it is extra expensive than Melanotan II.

Melanotan II binds to receptors other than those responsible for tanning and also for that reason leads to even more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untested drug the complete series of potential side-effects are unknown. Boosted sex drive, spontaneous erections, nausea (with succeeding fat burning), facial flushing on management, flu-like signs, and also enhanced blood pressure have been reported.

Just how is Melanotan provided?

Melanotan is carried out subcutaneously by injecting right into the fatty layer of cells around the stomach switch location. Customers infuse daily till a desired colour is attained and then remain to infuse one or two times a week to keep the colour.

Some darkening of the skin might take place making use of the shot alone yet the impacts are even more remarkable when utilized along with exposure to UV light (sun or tanning bed) 2-3 times a week originally and then 1-2 times a week afterwards.

Just how is Melanotan available?

Products on the marketplace consist of:

  • A multi- dosage vial of 10, 20 or 30 dosages for subcutaneous injection.
  • A collection of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Main concerns

Item pureness and also web content:

  • This is an unlicensed, unregulated product. This is a breakable medicine which requires refrigeration.
  • Customers may reluctant to place the product in their family members fridge. If pre-filled syringes are put in the refrigerator this has implications in regards to access of kids to syringes.

Unidentified side-effects:

  • There are no clinical tests available on the brief and long term effects of using these products or if the dosages advised by manufacturers are secure.
  • There is no trial data offered on how these items might communicate with other medications or their effect on an unborn youngster.

Infusing equipment

  • Needles made use of to infuse might also bring bodily liquids, which can hand down infections such as HIV as well as hepatitis. Sometimes, there is an undersupply of needles by the on the internet distributors for the quantity of management needed, e.g. 1 needle supplied with a 10 dose vial.
  • This might lead to sharing and reusing of needles. There are reports of customers using the exact same needle for a month as well as attempting to sterilise after every usage.
  • A multi-dose vial made in a non-rigorous production atmosphere may not stay sterile for the duration of its usage e.g. a 30mg vial is designed to be used for 30 dosages which might span a period of 10 weeks.
  • Some websites provide pre-filled syringes in which the item is currently re-constituted with bacteriostatic water, nonetheless there is no guarantee that these pre-filled items will certainly remain steady and also sterilized throughout distribution or for the life span of their usage.

Disposal of used sharps

There have been reports of needles being gotten rid of in household rubbish.

Raised exposure to UV rays

As the effects of the tanning agents are much more significant when used combined with exposure to UV light (by all-natural sunshine or by tanning beds) use of the agents may enhance UV direct exposure with all the enhancement threats connected such as increased threat of skin cancer, skin ageing, and so on

Injury reduction activities

  • Discuss to customers concerning the risks related to injectable tanning items.
  • Highlight the threats related to boosted UV exposure (the sick effects of tanning still happen also in clients that have a deep tan). Customers can speak to the Irish Cancer cells Society if they have problems concerning skin cancer on the cancer cells helpline 1800 200 700 or
  • Encourage customers to stop using, and also to seek clinical suggestions if needed.

If utilizing

Tidy injecting equipment:

  • Suggest that they use a clean needle each time as well as get rid of needles in a sharps container. The needles available in the injecting pack available in pharmacies joining the Drug store Needle Exchange Program are made like a diabetic needle and also are suitable for subcutaneous shot.
  • Advise clients on the threat of blood birthed conditions and also supply recommendations on whom to call if the client is concerned that they might have revealed themselves to a blood borne illness by sharing needles.
  • A checklist of pharmacies participating in your location is offered via the Medications helpline 1800 459 459.

Safe disposal.

The pack additionally has a tiny sharps container for utilized sharps. Drug stores will certainly accept utilized sharps if returned in the sharps container.

Pollutant and instability of product.

  • The quantity of item in the vial might differ substantially, might be polluted with germs or various other chemicals.
  • Examine the vial prior to usage and do not make use of if stained or if bits noticeable.
  • It has to be saved in the fridge.
  • All drugs need to be kept out of the reach of kids which might be tough in a fridge.


  • Encourage that side-effects are unknown, and the dosages being utilized may not be safe.
  • Effects of the drug on an unborn child are unidentified.
  • Impacts when taken with various other medicines are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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