Is Melanotan irreversible? – 2021

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Guidance on the usage on injecting tanning agents, e.g. Melanotan


Due to the recent publicity and warnings regarding the threats of infusing melanotan the HSE has actually launched information and advice on the use on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medication (afamelanotide) which was created by the University of Arizona in 1981 to be utilized for image defense against sunlight damage. This drug is currently undertaking professional trials for use in individuals with specific sun-sensitive skin problem and is not available for basic sale.

The drug is chemically connected to the alpha-melanocyte stimulating hormonal agent (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital role in determining skin and also hair coloring, boosts production of melanin in the skin, resulting in a ‘sun tan’.

Melanotan is an artificial analog of α-MSH and is prohibited, untried and unregulated which is currently being offered online for self-administration. α-MSH is extremely delicate and also requires a rigorous manufacturing atmosphere which can not be guaranteed in unlicensed manufacturing labs. The item needs to additionally be kept in a fridge.

What is the difference between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors responsible for tanning therefore has less adverse effects. Nevertheless a lot more of it is required for effect and therefore it is a lot more expensive than Melanotan II.

Melanotan II binds to receptors aside from those in charge of tanning and for that reason causes more side-effects.

What are the side-effects?

As this is an unregulated and also untested drug the full series of possible side-effects are unknown. Boosted sex drive, spontaneous erections, nausea (with subsequent weight loss), face flushing on administration, flu-like signs and symptoms, as well as increased blood pressure have been reported.

How is Melanotan provided?

Melanotan is provided subcutaneously by infusing into the fatty layer of tissue around the stubborn belly button location. Customers infuse daily up until a desired colour is attained and after that continue to infuse once or twice a week to preserve the colour.

Some dimming of the skin might take place making use of the shot alone but the effects are much more remarkable when used together with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week originally and after that 1-2 times a week afterwards.

Exactly how is Melanotan readily available?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Key problems

Item purity and material:

  • This is an unlicensed, unregulated product. This is a fragile medicine which needs refrigeration.
  • Customers may reluctant to put the product in their family refrigerator. If pre-filled syringes are put in the fridge this has ramifications in regards to accessibility of kids to syringes.

Unknown side-effects:

  • There are no clinical tests offered on the short and long term results of using these products or if the doses suggested by manufacturers are risk-free.
  • There is no test data offered on exactly how these items might engage with various other medicines or their effect on a coming youngster.

Injecting devices

  • Needles used to inject could also bring physical liquids, which can pass on infections such as HIV as well as hepatitis. Sometimes, there is an undersupply of needles by the on the internet distributors for the quantity of administration required, e.g. 1 needle supplied with a 10 dosage vial.
  • This can lead to sharing as well as recycling of needles. There are records of clients using the very same needle for a month and trying to sterilise after every usage.
  • A multi-dose vial produced in a non-rigorous manufacturing environment may not continue to be clean and sterile throughout of its usage e.g. a 30mg vial is designed to be made use of for 30 dosages which might span an amount of time of 10 weeks.
  • Some websites supply pre-filled syringes in which the product is already re-constituted with bacteriostatic water, however there is no guarantee that these pre-filled items will certainly continue to be secure and also clean and sterile during shipment or for the life span of their usage.

Disposal of used sharps

There have been reports of needles being thrown away in household rubbish.

Boosted exposure to UV rays

As the results of the tanning agents are extra dramatic when used in conjunction with exposure to UV light (by all-natural sunlight or by tanning beds) use the agents may increase UV direct exposure with all the enhancement risks linked such as enhanced risk of skin cancer, skin ageing, etc

Harm decrease activities

  • Describe to individuals concerning the threats associated with injectable tanning products.
  • Highlight the threats related to boosted UV direct exposure (the ill effects of sun tanning still happen also in clients who have a deep tan). Clients can get in touch with the Irish Cancer cells Society if they have problems regarding skin cancer cells on the cancer cells helpline 1800 200 700 or
  • Encourage users to stop making use of, and to look for clinical recommendations if needed.

If using

Clean infusing devices:

  • Recommend that they utilize a clean needle each time as well as throw away needles in a sharps container. The needles offered in the injecting pack available in drug stores joining the Pharmacy Needle Exchange Program are created like a diabetic needle and also are suitable for subcutaneous shot.
  • Encourage clients on the threat of blood borne diseases as well as offer suggestions on whom to speak to if the client is worried that they may have subjected themselves to a blood birthed disease by sharing needles.
  • A listing of drug stores participating in your area is offered via the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally includes a tiny sharps container for utilized sharps. Drug stores will approve utilized sharps if returned in the sharps container.

Contamination as well as instability of product.

  • The amount of product in the vial may differ considerably, may be infected with germs or various other chemicals.
  • Check the vial before use and do not use if discolored or if fragments noticeable.
  • It needs to be stored in the refrigerator.
  • All medicines need to be stayed out of the reach of kids which may be challenging in a fridge.


  • Advise that side-effects are unidentified, as well as the doses being utilized might not be risk-free.
  • Results of the medication on an expected kid are unidentified.
  • Impacts when taken with various other medicines are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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