Is Melanotan legal? – 2021

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Recommendations on the use on injecting tanning representatives, e.g. Melanotan


Because of the current attention and also cautions regarding the risks of infusing melanotan the HSE has released info as well as recommendations on the usage on injecting tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a drug (afamelanotide) which was created by the University of Arizona in 1981 to be used for photo protection versus sun damage. This medication is currently undergoing clinical tests for use in clients with certain sun-sensitive skin problem as well as is not readily available for basic sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) as well as binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital role in determining skin and hair pigmentation, increases production of melanin in the skin, leading to a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH as well as is unlawful, untried and uncontrolled which is currently being offered online for self-administration. α-MSH is very vulnerable and requires a strenuous production atmosphere which can not be ensured in unlicensed manufacturing research laboratories. The product needs to likewise be kept in a fridge.

What is the distinction between Melanotan I as well as Melanotan II?

Melanotan I particularly binds to receptors in charge of tanning and so has less adverse effects. Nonetheless a lot more of it is required for result as well as for that reason it is extra expensive than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning and consequently causes more side-effects.

What are the side-effects?

As this is an uncontrolled as well as untested medicine the full series of possible side-effects are unknown. Enhanced libido, spontaneous erections, queasiness (with subsequent fat burning), face flushing on management, flu-like symptoms, and also enhanced high blood pressure have been reported.

How is Melanotan provided?

Melanotan is provided subcutaneously by infusing right into the fatty layer of cells around the belly switch area. Customers inject daily until a desired colour is achieved and then continue to inject one or two times a week to keep the colour.

Some darkening of the skin might happen utilizing the shot alone however the effects are much more dramatic when made use of together with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week after that.

How is Melanotan available?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A collection of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main concerns

Product purity and also material:

  • This is an unlicensed, unregulated item. This is a breakable medicine which needs refrigeration.
  • Customers might hesitant to position the product in their family fridge. If pre-filled syringes are put in the fridge this has effects in terms of access of kids to syringes.

Unknown side-effects:

  • There are no professional trials readily available on the brief and also long-term effects of using these items or if the doses recommended by suppliers are safe.
  • There is no trial information readily available on exactly how these items may interact with other medications or their effect on a coming youngster.

Injecting equipment

  • Needles made use of to inject can also bring physical liquids, which can hand down infections such as HIV as well as hepatitis. In some cases, there is an undersupply of needles by the online providers for the quantity of administration called for, e.g. 1 needle supplied with a 10 dosage vial.
  • This can lead to sharing and also reusing of needles. There are records of clients utilizing the same needle for a month and also trying to sterilise after every use.
  • A multi-dose vial produced in a non-rigorous manufacturing setting may not stay sterile for the duration of its use e.g. a 30mg vial is created to be used for 30 dosages which may cover a time period of 10 weeks.
  • Some websites use pre-filled syringes in which the item is currently re-constituted with bacteriostatic water, however there is no assurance that these pre-filled products will stay stable and sterilized throughout delivery or for the life span of their use.

Disposal of used sharps

There have actually been records of needles being thrown away in household rubbish.

Boosted exposure to UV rays

As the impacts of the tanning agents are extra dramatic when utilized along with direct exposure to UV light (by natural sunlight or by tanning beds) use of the agents might enhance UV exposure with all the enhancement risks associated such as raised danger of skin cancer cells, skin ageing, and so on

Injury decrease activities

  • Describe to individuals concerning the dangers associated with injectable tanning products.
  • Highlight the risks related to enhanced UV direct exposure (the unwell effects of tanning still occur also in customers who have a deep tan). Customers can call the Irish Cancer cells Culture if they have problems pertaining to skin cancer cells on the cancer cells helpline 1800 200 700 or
  • Encourage individuals to stop using, and to seek medical suggestions if required.

If utilizing

Tidy infusing devices:

  • Encourage that they make use of a tidy needle every time and dispose of needles in a sharps container. The needles available in the injecting pack readily available in drug stores participating in the Drug store Needle Exchange Program are created like a diabetic person needle and appropriate for subcutaneous injection.
  • Recommend clients on the risk of blood borne diseases and also use guidance on whom to contact if the client is worried that they might have subjected themselves to a blood borne illness by sharing needles.
  • A listing of drug stores joining your area is offered via the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally contains a little sharps container for utilized sharps. Drug stores will certainly accept used sharps if returned in the sharps container.

Contamination as well as instability of item.

  • The amount of item in the vial might differ significantly, may be infected with bacteria or various other chemicals.
  • Inspect the vial before use and do not utilize if blemished or if particles noticeable.
  • It must be saved in the fridge.
  • All drugs should be kept out of the reach of kids which may be difficult in a refrigerator.


  • Suggest that side-effects are unknown, and also the dosages being used may not be risk-free.
  • Effects of the medication on a coming youngster are unknown.
  • Results when taken with various other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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