Is Melanotan Nasal Spray Safe? – 2021


When you tan your whole body, you’re exposing all your skin to hazardous UV rays. If your skin on a regular basis gets subjected to UV rays way too much, it’ll create wellness issues and skin issues for you.

Luckily, Melanotan peptide can assist you handle these tanning issues by enabling your body to boost its manufacturing of melanin. Whenever your body endures UV damages, it naturally reacts by generating melanin. This is a peptide hormone which normally dims the skin in order to shield it from the damaging UV rays.


Recommendations on the usage on infusing tanning agents, e.g. Melanotan


Due to the current promotion and cautions about the risks of infusing melanotan the HSE has actually launched information as well as guidance on the usage on infusing tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medicine (afamelanotide) which was established by the University of Arizona in 1981 to be used for picture protection versus sunlight damages. This medication is presently undergoing medical tests for usage in individuals with specific sun-sensitive skin conditions and is not available for basic sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential role in figuring out skin and also hair coloring, enhances manufacturing of melanin in the skin, leading to a ‘sun tan’.

Melanotan is an artificial analog of α-MSH and is illegal, untried and also uncontrolled which is currently being marketed online for self-administration. α-MSH is really fragile and also calls for a rigorous manufacturing atmosphere which can not be guaranteed in unlicensed production labs. The item has to additionally be stored in a fridge.

What is the distinction between Melanotan I as well as Melanotan II?

Melanotan I especially binds to receptors in charge of tanning and so has much less negative effects. However a lot more of it is needed for impact and also as a result it is extra expensive than Melanotan II.

Melanotan II binds to receptors apart from those in charge of tanning and also as a result leads to even more side-effects.

What are the side-effects?

As this is an unregulated and untried medicine the complete range of possible side-effects are unknown. Raised sex drive, spontaneous erections, nausea (with subsequent weight-loss), facial flushing on management, flu-like signs and symptoms, as well as increased high blood pressure have actually been reported.

Just how is Melanotan administered?

Melanotan is administered subcutaneously by injecting right into the fatty layer of tissue around the stubborn belly switch location. Customers inject daily till a wanted colour is achieved and afterwards remain to infuse once or twice a week to keep the colour.

Some dimming of the skin might take place using the shot alone yet the effects are even more remarkable when utilized together with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and then 1-2 times a week thereafter.

How is Melanotan offered?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key worries

Item pureness as well as web content:

  • This is an unlicensed, uncontrolled product. This is a delicate medicine which requires refrigeration.
  • Users may reluctant to put the item in their family refrigerator. If pre-filled syringes are put in the fridge this has effects in terms of accessibility of kids to syringes.

Unknown side-effects:

  • There are no clinical trials offered on the short as well as long term results of using these items or if the dosages suggested by producers are risk-free.
  • There is no test data readily available on exactly how these products might engage with various other medicines or their result on an unborn child.

Injecting tools

  • Needles made use of to inject could additionally lug bodily liquids, which can hand down infections such as HIV and liver disease. Sometimes, there is an undersupply of needles by the on the internet distributors for the amount of management required, e.g. 1 needle supplied with a 10 dose vial.
  • This can cause sharing and reusing of needles. There are records of clients utilizing the exact same needle for a month and also trying to sterilise after every usage.
  • A multi-dose vial manufactured in a non-rigorous manufacturing atmosphere might not stay clean and sterile throughout of its use e.g. a 30mg vial is designed to be used for 30 dosages which may cover a time period of 10 weeks.
  • Some websites provide pre-filled syringes in which the product is already re-constituted with bacteriostatic water, nevertheless there is no assurance that these pre-filled items will certainly remain stable as well as sterile throughout distribution or for the life span of their use.

Disposal of used sharps

There have actually been reports of needles being taken care of in family rubbish.

Raised exposure to UV rays

As the effects of the tanning representatives are much more remarkable when made use of in conjunction with direct exposure to UV light (by all-natural sunlight or by tanning beds) use the agents might raise UV exposure with all the enhancement risks connected such as raised threat of skin cancer cells, skin ageing, etc

Injury decrease activities

  • Explain to customers regarding the threats connected with injectable tanning items.
  • Highlight the risks associated with enhanced UV exposure (the unwell effects of sun tanning still occur even in clients who have a deep tan). Clients can speak to the Irish Cancer Society if they have problems concerning skin cancer cells on the cancer helpline 1800 200 700 or
  • Encourage individuals to quit making use of, as well as to look for clinical guidance if needed.

If utilizing

Clean infusing devices:

  • Suggest that they use a tidy needle each time and throw away needles in a sharps container. The needles readily available in the infusing pack offered in drug stores participating in the Pharmacy Needle Exchange Program are created like a diabetic person needle as well as are suitable for subcutaneous shot.
  • Encourage clients on the risk of blood borne illness and also provide recommendations on whom to speak to if the client is concerned that they may have subjected themselves to a blood borne illness by sharing needles.
  • A checklist of drug stores participating in your location is available through the Medicines helpline 1800 459 459.

Safe disposal.

The pack additionally has a little sharps container for made use of sharps. Pharmacies will accept used sharps if returned in the sharps container.

Pollutant and also instability of product.

  • The amount of product in the vial may differ significantly, may be contaminated with bacteria or various other chemicals.
  • Check the vial before use as well as do not make use of if blemished or if particles visible.
  • It should be saved in the fridge.
  • All medications should be shut out of the reach of children which might be difficult in a refrigerator.


  • Suggest that side-effects are unknown, and also the doses being made use of might not be secure.
  • Impacts of the drug on an unborn child are unidentified.
  • Impacts when taken with other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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