The length of time does Melanotan last? – 2021

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Suggestions on the usage on injecting tanning representatives, e.g. Melanotan


Because of the current publicity and warnings about the risks of injecting melanotan the HSE has actually released details and recommendations on the use on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medication (afamelanotide) which was established by the University of Arizona in 1981 to be made use of for picture security versus sunlight damage. This medication is currently going through scientific tests for usage in patients with specific sun-sensitive skin disease and also is not readily available for basic sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormone (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential function in identifying skin as well as hair coloring, boosts production of melanin in the skin, leading to a ‘sunlight tan’.

Melanotan is a synthetic analog of α-MSH and is prohibited, untried as well as uncontrolled which is currently being offered online for self-administration. α-MSH is very breakable and also needs a rigorous manufacturing setting which can not be guaranteed in unlicensed manufacturing research laboratories. The product must also be stored in a refrigerator.

What is the distinction between Melanotan I and Melanotan II?

Melanotan I especially binds to receptors responsible for tanning and so has much less negative effects. Nonetheless far more of it is needed for result and for that reason it is more pricey than Melanotan II.

Melanotan II binds to receptors besides those responsible for tanning as well as for that reason results in more side-effects.

What are the side-effects?

As this is an uncontrolled and also untested medicine the full series of potential side-effects are unidentified. Raised sex drive, spontaneous erections, nausea or vomiting (with subsequent weight-loss), facial flushing on management, flu-like symptoms, as well as enhanced high blood pressure have been reported.

Exactly how is Melanotan provided?

Melanotan is provided subcutaneously by infusing into the fatty layer of cells around the belly switch area. Clients inject daily up until a preferred colour is attained and afterwards continue to infuse one or two times a week to preserve the colour.

Some dimming of the skin might happen making use of the shot alone however the effects are much more remarkable when used along with exposure to UV light (sun or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week after that.

How is Melanotan offered?

Products on the marketplace consist of:

  • A multi- dosage vial of 10, 20 or 30 dosages for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key worries

Product pureness and material:

  • This is an unlicensed, unregulated item. This is a vulnerable medicine which requires refrigeration.
  • Customers might hesitant to position the product in their family refrigerator. If pre-filled syringes are positioned in the refrigerator this has implications in regards to gain access to of kids to syringes.

Unidentified side-effects:

  • There are no clinical trials available on the short and long-term impacts of using these products or if the doses advised by makers are safe.
  • There is no test data readily available on just how these items might connect with other medications or their result on a coming child.

Injecting tools

  • Needles used to infuse might likewise bring bodily fluids, which can pass on infections such as HIV as well as hepatitis. In many cases, there is an undersupply of needles by the on the internet suppliers for the quantity of administration needed, e.g. 1 needle provided with a 10 dosage vial.
  • This can result in sharing and reusing of needles. There are records of customers using the exact same needle for a month and attempting to sterilise after every use.
  • A multi-dose vial made in a non-rigorous manufacturing atmosphere might not stay clean and sterile for the duration of its usage e.g. a 30mg vial is made to be used for 30 doses which may cover a time period of 10 weeks.
  • Some sites offer pre-filled syringes in which the item is already re-constituted with bacteriostatic water, however there is no assurance that these pre-filled products will certainly continue to be secure and also clean and sterile during delivery or for the lifetime of their usage.

Disposal of used sharps

There have actually been records of needles being disposed of in family rubbish.

Boosted exposure to UV rays

As the impacts of the tanning representatives are much more significant when made use of along with direct exposure to UV light (by all-natural sunshine or by tanning beds) use of the representatives might enhance UV direct exposure with all the addition dangers connected such as increased risk of skin cancer cells, skin ageing, etc

Damage reduction activities

  • Describe to users regarding the risks connected with injectable tanning products.
  • Highlight the threats related to enhanced UV direct exposure (the sick impacts of tanning still take place also in clients who have a deep tan). Clients can contact the Irish Cancer Culture if they have issues concerning skin cancer cells on the cancer helpline 1800 200 700 or
  • Encourage users to quit utilizing, and also to look for clinical suggestions if needed.

If making use of

Tidy injecting equipment:

  • Recommend that they make use of a tidy needle whenever as well as deal with needles in a sharps container. The needles available in the injecting pack offered in drug stores joining the Pharmacy Needle Exchange Program are designed like a diabetic person needle and appropriate for subcutaneous shot.
  • Encourage customers on the danger of blood birthed conditions and provide guidance on whom to call if the client is concerned that they may have revealed themselves to a blood borne disease by sharing needles.
  • A checklist of drug stores taking part in your area is readily available through the Drugs helpline 1800 459 459.

Safe disposal.

The pack additionally contains a small sharps container for utilized sharps. Pharmacies will certainly accept used sharps if returned in the sharps container.

Contamination and instability of product.

  • The amount of product in the vial may vary significantly, might be contaminated with bacteria or other chemicals.
  • Check the vial before use and do not use if blemished or if particles noticeable.
  • It must be saved in the fridge.
  • All medicines must be kept out of the reach of youngsters which may be hard in a fridge.


  • Advise that side-effects are unidentified, as well as the dosages being used might not be risk-free.
  • Results of the medication on an expected child are unidentified.
  • Results when taken with various other medications are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause. Products:

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