What are the adverse effects of Melanotan? – Melanotan.eu


When you tan your entire body, you’re subjecting all your skin to harmful UV rays. If your skin on a regular basis gets exposed to UV rays too much, it’ll cause health and wellness issues as well as skin issues for you.

The good news is, Melanotan peptide can assist you handle these tanning issues by enabling your body to raise its production of melanin. Whenever your body suffers UV damages, it naturally responds by producing melanin. This is a peptide hormonal agent which normally dims the skin in order to secure it from the destructive UV rays.


Recommendations on the usage on infusing tanning representatives, e.g. Melanotan


As a result of the recent promotion as well as warnings concerning the dangers of infusing melanotan the HSE has actually launched details as well as advice on the usage on injecting tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a medicine (afamelanotide) which was created by the College of Arizona in 1981 to be made use of for picture protection against sunlight damages. This medication is currently undergoing scientific trials for usage in clients with particular sun-sensitive skin problem and also is not readily available for basic sale.

The drug is chemically associated with the alpha-melanocyte stimulating hormone (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital function in identifying skin and also hair pigmentation, boosts manufacturing of melanin in the skin, resulting in a ‘sun tan’.

Melanotan is an artificial analog of α-MSH and also is prohibited, untried and also unregulated which is currently being offered online for self-administration. α-MSH is very breakable as well as requires a strenuous production setting which can not be assured in unlicensed manufacturing laboratories. The item needs to also be kept in a fridge.

What is the distinction in between Melanotan I and also Melanotan II?

Melanotan I especially binds to receptors responsible for tanning therefore has much less adverse effects. Nonetheless much more of it is required for result as well as therefore it is more costly than Melanotan II.

Melanotan II binds to receptors apart from those in charge of tanning as well as consequently results in even more side-effects.

What are the side-effects?

As this is an unregulated and also untested drug the complete variety of prospective side-effects are unidentified. Boosted libido, spontaneous erections, queasiness (with succeeding weight-loss), facial flushing on management, flu-like signs, as well as boosted blood pressure have been reported.

Just how is Melanotan carried out?

Melanotan is provided subcutaneously by injecting right into the fatty layer of tissue around the tummy button location. Customers inject daily till a wanted colour is attained and then continue to inject one or two times a week to keep the colour.

Some dimming of the skin may happen utilizing the injection alone but the effects are far more significant when utilized along with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week originally and after that 1-2 times a week after that.

How is Melanotan available?

Products on the marketplace include:

  • A multi- dosage vial of 10, 20 or 30 dosages for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Key worries

Item purity and also web content:

  • This is an unlicensed, uncontrolled item. This is a delicate medication which calls for refrigeration.
  • Customers may unwilling to put the item in their family fridge. If pre-filled syringes are put in the fridge this has ramifications in terms of gain access to of youngsters to syringes.

Unknown side-effects:

  • There are no scientific trials available on the short as well as long-term results of using these products or if the doses suggested by manufacturers are safe.
  • There is no test data offered on exactly how these products may communicate with other medicines or their impact on a coming child.

Injecting equipment

  • Needles used to inject could also bring physical fluids, which can pass on infections such as HIV and also hepatitis. In some cases, there is an undersupply of needles by the on the internet suppliers for the amount of management needed, e.g. 1 needle provided with a 10 dosage vial.
  • This could lead to sharing and also reusing of needles. There are records of clients using the exact same needle for a month as well as attempting to sterilise after every usage.
  • A multi-dose vial made in a non-rigorous production atmosphere may not continue to be sterile throughout of its use e.g. a 30mg vial is created to be utilized for 30 doses which may span an amount of time of 10 weeks.
  • Some websites supply pre-filled syringes in which the product is already re-constituted with bacteriostatic water, however there is no warranty that these pre-filled products will certainly remain steady and clean and sterile throughout distribution or for the lifetime of their use.

Disposal of used sharps

There have been reports of needles being thrown away in house rubbish.

Enhanced direct exposure to UV rays

As the impacts of the tanning agents are more significant when utilized in conjunction with exposure to UV light (by all-natural sunlight or by tanning beds) use the representatives might increase UV exposure with all the enhancement threats associated such as increased danger of skin cancer, skin ageing, etc

Damage reduction activities

  • Discuss to users about the threats associated with injectable tanning items.
  • Highlight the threats associated with enhanced UV direct exposure (the sick results of sun tanning still occur also in customers that have a deep tan). Customers can contact the Irish Cancer cells Society if they have issues concerning skin cancer on the cancer helpline 1800 200 700 or www.cancer.ie
  • Motivate individuals to stop making use of, and also to look for clinical guidance if needed.

If making use of

Tidy infusing tools:

  • Encourage that they make use of a tidy needle whenever as well as take care of needles in a sharps container. The needles available in the injecting pack offered in drug stores taking part in the Drug store Needle Exchange Program are designed like a diabetic person needle and also are suitable for subcutaneous injection.
  • Encourage clients on the risk of blood borne conditions and use recommendations on whom to contact if the client is worried that they may have revealed themselves to a blood birthed condition by sharing needles.
  • A list of drug stores joining your area is readily available through the Drugs helpline 1800 459 459.

Safe disposal.

The pack likewise contains a little sharps container for utilized sharps. Pharmacies will approve used sharps if returned in the sharps container.

Impurity as well as instability of item.

  • The quantity of product in the vial might differ considerably, might be infected with microorganisms or other chemicals.
  • Examine the vial prior to use and also do not use if stained or if fragments noticeable.
  • It has to be stored in the refrigerator.
  • All medications need to be stayed out of the reach of kids which may be challenging in a fridge.


  • Recommend that side-effects are unknown, as well as the dosages being used might not be secure.
  • Effects of the medicine on an expected child are unidentified.
  • Effects when taken with various other drugs are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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