What is the distinction between Melanotan 1 and 2? – 2021

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Our tanning service, Melanotan 2 additionally called MT2 is a widely popular remedy that will certainly boost the body’s all-natural tanning abilities, which then permits you to tan with very little sunshine


Recommendations on the usage on injecting tanning agents, e.g. Melanotan


As a result of the recent publicity as well as warnings concerning the risks of infusing melanotan the HSE has actually launched info as well as guidance on the use on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medication (afamelanotide) which was created by the College of Arizona in 1981 to be made use of for photo security versus sun damage. This medication is currently undergoing medical tests for use in people with details sun-sensitive skin conditions as well as is not available for basic sale.

The drug is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a key role in establishing skin and hair coloring, raises production of melanin in the skin, resulting in a ‘sunlight tan’.

Melanotan is a synthetic analog of α-MSH as well as is illegal, untested and also unregulated which is presently being marketed online for self-administration. α-MSH is really fragile as well as calls for a rigorous production environment which can not be assured in unlicensed production labs. The item must additionally be stored in a refrigerator.

What is the distinction between Melanotan I and also Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning and so has much less negative effects. Nonetheless a lot more of it is needed for result and therefore it is extra expensive than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning and also therefore causes more side-effects.

What are the side-effects?

As this is an uncontrolled and also untested medication the full variety of prospective side-effects are unidentified. Raised sex drive, spontaneous erections, queasiness (with subsequent weight-loss), facial flushing on administration, flu-like signs and symptoms, as well as increased blood pressure have actually been reported.

How is Melanotan carried out?

Melanotan is carried out subcutaneously by injecting into the fatty layer of cells around the stomach button area. Clients inject daily up until a preferred colour is attained and then continue to infuse once or twice a week to keep the colour.

Some dimming of the skin may take place making use of the injection alone yet the impacts are even more significant when utilized together with exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week after that.

Just how is Melanotan available?

Products on the marketplace consist of:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous injection.
  • A set of pre-filled syringes for subcutaneous injection.
  • A nasal spray.

Main worries

Product purity as well as content:

  • This is an unlicensed, unregulated product. This is a vulnerable medicine which needs refrigeration.
  • Users may unwilling to position the product in their family fridge. If pre-filled syringes are positioned in the refrigerator this has ramifications in terms of accessibility of children to syringes.

Unidentified side-effects:

  • There are no professional tests available on the short as well as long term results of using these items or if the dosages recommended by makers are safe.
  • There is no trial data available on just how these products might connect with other medications or their impact on a coming youngster.

Injecting equipment

  • Needles used to infuse could likewise lug bodily fluids, which can hand down infections such as HIV as well as hepatitis. Sometimes, there is an undersupply of needles by the online vendors for the quantity of administration called for, e.g. 1 needle provided with a 10 dose vial.
  • This could bring about sharing as well as reusing of needles. There are reports of clients making use of the same needle for a month as well as attempting to sterilise after every use.
  • A multi-dose vial manufactured in a non-rigorous manufacturing atmosphere may not remain sterile for the duration of its use e.g. a 30mg vial is developed to be utilized for 30 dosages which might span a period of 10 weeks.
  • Some sites use pre-filled syringes in which the product is already re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled products will certainly stay stable and also sterile throughout delivery or for the lifetime of their use.

Disposal of used sharps

There have been reports of needles being thrown away in house rubbish.

Increased direct exposure to UV rays

As the impacts of the tanning agents are much more remarkable when used together with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the agents might raise UV exposure with all the addition risks connected such as raised threat of skin cancer, skin ageing, etc

Injury reduction activities

  • Describe to individuals about the threats related to injectable tanning items.
  • Highlight the risks related to boosted UV direct exposure (the unwell impacts of sun tanning still happen also in clients who have a deep tan). Customers can call the Irish Cancer Society if they have issues regarding skin cancer on the cancer cells helpline 1800 200 700 or www.cancer.ie
  • Encourage users to stop making use of, and to seek medical advice if needed.

If using

Clean injecting equipment:

  • Recommend that they make use of a tidy needle whenever as well as dispose of needles in a sharps container. The needles available in the infusing pack readily available in drug stores taking part in the Pharmacy Needle Exchange Program are created like a diabetic needle and are suitable for subcutaneous shot.
  • Suggest clients on the threat of blood birthed illness and also supply guidance on whom to contact if the client is worried that they may have exposed themselves to a blood borne disease by sharing needles.
  • A listing of pharmacies participating in your location is available via the Drugs helpline 1800 459 459.

Safe disposal.

The pack also consists of a little sharps container for used sharps. Drug stores will certainly approve utilized sharps if returned in the sharps container.

Contamination as well as instability of product.

  • The quantity of item in the vial might vary considerably, may be contaminated with microorganisms or other chemicals.
  • Examine the vial before usage as well as do not utilize if discolored or if particles visible.
  • It must be stored in the fridge.
  • All medicines should be shut out of the reach of youngsters which might be challenging in a fridge.


  • Advise that side-effects are unidentified, and the dosages being made use of may not be safe.
  • Results of the medication on an expected youngster are unknown.
  • Effects when taken with other medicines are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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