What occurs if you infuse excessive Melanotan 2?

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When you tan your entire body, you’re exposing all your skin to unsafe UV rays. If your skin consistently gets revealed to UV rays excessive, it’ll trigger health and wellness concerns as well as skin problems for you.

Luckily, Melanotan peptide can aid you deal with these tanning problems by permitting your body to boost its production of melanin. Whenever your body suffers UV damages, it naturally reacts by producing melanin. This is a peptide hormonal agent which normally dims the skin in order to secure it from the damaging UV rays.


Guidance on the usage on injecting tanning representatives, e.g. Melanotan


Because of the current publicity as well as cautions about the threats of injecting melanotan the HSE has actually launched info as well as recommendations on the use on infusing tanning representatives, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a drug (afamelanotide) which was created by the College of Arizona in 1981 to be made use of for photo defense against sunlight damage. This medicine is currently undertaking professional trials for usage in patients with certain sun-sensitive skin problem as well as is not readily available for basic sale.

The drug is chemically associated with the alpha-melanocyte stimulating hormone (α-MSH) as well as binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has an essential function in determining skin and also hair pigmentation, raises production of melanin in the skin, resulting in a ‘sun tan’.

Melanotan is an artificial analog of α-MSH and also is prohibited, untested as well as unregulated which is presently being marketed online for self-administration. α-MSH is very fragile and requires a strenuous manufacturing environment which can not be guaranteed in unlicensed manufacturing research laboratories. The product must likewise be kept in a refrigerator.

What is the difference in between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning therefore has much less adverse effects. However a lot more of it is needed for effect and therefore it is extra pricey than Melanotan II.

Melanotan II binds to receptors aside from those in charge of tanning and also as a result results in more side-effects.

What are the side-effects?

As this is an uncontrolled and untried drug the full series of potential side-effects are unidentified. Raised sex drive, spontaneous erections, nausea (with subsequent weight management), face flushing on administration, flu-like signs, as well as boosted blood pressure have been reported.

How is Melanotan provided?

Melanotan is administered subcutaneously by infusing into the fatty layer of cells around the belly button location. Customers inject daily till a desired colour is accomplished and afterwards remain to infuse once or twice a week to keep the colour.

Some dimming of the skin might take place making use of the shot alone yet the impacts are even more remarkable when utilized together with direct exposure to UV light (sun or tanning bed) 2-3 times a week initially and then 1-2 times a week after that.

Just how is Melanotan offered?

Products on the market consist of:

  • A multi- dose vial of 10, 20 or 30 dosages for subcutaneous injection.
  • A collection of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Main worries

Product purity and also web content:

  • This is an unlicensed, unregulated item. This is a breakable medicine which needs refrigeration.
  • Individuals may hesitant to position the item in their household fridge. If pre-filled syringes are put in the fridge this has implications in terms of access of youngsters to syringes.

Unknown side-effects:

  • There are no medical trials offered on the short and long-term effects of using these products or if the dosages advised by suppliers are secure.
  • There is no test information readily available on how these products might interact with other medicines or their result on a coming child.

Injecting devices

  • Needles utilized to inject might additionally carry physical fluids, which can pass on infections such as HIV and also hepatitis. In some cases, there is an undersupply of needles by the on-line suppliers for the quantity of management called for, e.g. 1 needle provided with a 10 dosage vial.
  • This might result in sharing and reusing of needles. There are records of clients making use of the same needle for a month and also attempting to sterilise after every use.
  • A multi-dose vial produced in a non-rigorous manufacturing environment may not remain sterile for the duration of its use e.g. a 30mg vial is made to be used for 30 dosages which might cover a time period of 10 weeks.
  • Some websites use pre-filled syringes in which the item is currently re-constituted with bacteriostatic water, nonetheless there is no guarantee that these pre-filled products will continue to be stable and also sterilized throughout delivery or for the lifetime of their usage.

Disposal of used sharps

There have been records of needles being disposed of in family rubbish.

Boosted exposure to UV rays

As the results of the tanning agents are a lot more remarkable when made use of together with exposure to UV light (by natural sunlight or by tanning beds) use the agents may raise UV exposure with all the enhancement risks associated such as enhanced threat of skin cancer cells, skin ageing, etc

Injury reduction activities

  • Describe to individuals regarding the threats related to injectable tanning items.
  • Highlight the dangers associated with raised UV exposure (the ill impacts of sun tanning still occur also in customers who have a deep tan). Clients can call the Irish Cancer cells Culture if they have concerns regarding skin cancer on the cancer helpline 1800 200 700 or www.cancer.ie
  • Encourage individuals to stop using, as well as to seek medical advice if needed.

If using

Tidy infusing tools:

  • Advise that they use a tidy needle whenever as well as take care of needles in a sharps container. The needles offered in the injecting pack available in drug stores participating in the Drug store Needle Exchange Program are developed like a diabetic person needle as well as appropriate for subcutaneous injection.
  • Suggest customers on the risk of blood borne conditions and also use advice on whom to contact if the customer is worried that they might have subjected themselves to a blood birthed condition by sharing needles.
  • A list of drug stores taking part in your location is readily available with the Medicines helpline 1800 459 459.

Safe disposal.

The pack likewise contains a tiny sharps container for made use of sharps. Drug stores will approve used sharps if returned in the sharps container.

Impurity as well as instability of product.

  • The amount of product in the vial may vary significantly, might be polluted with microorganisms or other chemicals.
  • Examine the vial before use and do not utilize if stained or if bits noticeable.
  • It needs to be stored in the refrigerator.
  • All medicines must be kept out of the reach of kids which might be hard in a fridge.


  • Advise that side-effects are unknown, and the doses being used may not be safe.
  • Impacts of the drug on a coming kid are unidentified.
  • Impacts when taken with various other drugs are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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