What takes place if you inject excessive Melanotan 2? – Melanotan.eu

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When you tan your entire body, you’re subjecting all your skin to hazardous UV rays. If your skin routinely obtains revealed to UV rays way too much, it’ll trigger health problems and also skin issues for you.

Fortunately, Melanotan peptide can help you handle these tanning problems by permitting your body to enhance its production of melanin. Whenever your body endures UV damages, it normally responds by producing melanin. This is a peptide hormonal agent which normally darkens the skin in order to shield it from the destructive UV rays.


Recommendations on the usage on injecting tanning agents, e.g. Melanotan


Due to the current attention and also warnings regarding the dangers of injecting melanotan the HSE has launched info and also guidance on the usage on injecting tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medicine (afamelanotide) which was developed by the College of Arizona in 1981 to be made use of for picture security versus sun damage. This medication is presently undergoing professional tests for usage in people with details sun-sensitive skin problem as well as is not readily available for general sale.

The medicine is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a crucial function in identifying skin and also hair coloring, raises production of melanin in the skin, leading to a ‘sun tan’.

Melanotan is a synthetic analog of α-MSH and is illegal, untried and also unregulated which is presently being offered online for self-administration. α-MSH is really fragile and also requires a rigorous manufacturing atmosphere which can not be guaranteed in unlicensed manufacturing labs. The product has to additionally be kept in a fridge.

What is the difference in between Melanotan I as well as Melanotan II?

Melanotan I specifically binds to receptors responsible for tanning therefore has much less negative effects. However much more of it is needed for result as well as consequently it is a lot more expensive than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning as well as for that reason causes even more side-effects.

What are the side-effects?

As this is an unregulated as well as untried medicine the complete range of potential side-effects are unknown. Raised libido, spontaneous erections, queasiness (with succeeding weight management), facial flushing on management, flu-like signs, and also enhanced high blood pressure have actually been reported.

Just how is Melanotan carried out?

Melanotan is carried out subcutaneously by injecting into the fatty layer of tissue around the stomach switch location. Clients inject daily till a wanted colour is achieved and then continue to infuse once or twice a week to preserve the colour.

Some darkening of the skin might take place utilizing the shot alone yet the results are far more dramatic when made use of in addition to direct exposure to UV light (sun or tanning bed) 2-3 times a week at first and afterwards 1-2 times a week afterwards.

Just how is Melanotan readily available?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Main concerns

Product pureness as well as material:

  • This is an unlicensed, unregulated item. This is a delicate drug which calls for refrigeration.
  • Users might reluctant to position the product in their household fridge. If pre-filled syringes are positioned in the refrigerator this has implications in terms of gain access to of youngsters to syringes.

Unidentified side-effects:

  • There are no scientific tests available on the short and long term results of using these products or if the dosages suggested by producers are safe.
  • There is no test information offered on just how these items might interact with various other medicines or their effect on an unborn child.

Infusing devices

  • Needles utilized to infuse could additionally carry physical liquids, which can pass on infections such as HIV and also liver disease. Sometimes, there is an undersupply of needles by the on-line providers for the quantity of administration called for, e.g. 1 needle supplied with a 10 dose vial.
  • This could cause sharing and also recycling of needles. There are records of clients using the very same needle for a month as well as trying to sterilise after every usage.
  • A multi-dose vial produced in a non-rigorous manufacturing atmosphere might not continue to be clean and sterile throughout of its usage e.g. a 30mg vial is developed to be utilized for 30 doses which may cover a time period of 10 weeks.
  • Some sites use pre-filled syringes in which the product is already re-constituted with bacteriostatic water, nonetheless there is no assurance that these pre-filled items will certainly continue to be stable as well as clean and sterile during distribution or for the life expectancy of their usage.

Disposal of used sharps

There have been reports of needles being gotten rid of in house rubbish.

Raised exposure to UV rays

As the effects of the tanning representatives are extra significant when utilized in conjunction with exposure to UV light (by natural sunshine or by tanning beds) use of the representatives may boost UV exposure with all the enhancement risks linked such as raised threat of skin cancer cells, skin ageing, and so on

Injury decrease actions

  • Clarify to individuals about the risks related to injectable tanning items.
  • Highlight the dangers related to boosted UV direct exposure (the unwell results of tanning still occur also in clients that have a deep tan). Clients can get in touch with the Irish Cancer Culture if they have worries regarding skin cancer on the cancer cells helpline 1800 200 700 or www.cancer.ie
  • Motivate individuals to stop using, and also to look for medical advice if required.

If using

Tidy injecting tools:

  • Encourage that they use a clean needle every single time and dispose of needles in a sharps container. The needles available in the injecting pack available in drug stores joining the Drug store Needle Exchange Program are created like a diabetic person needle as well as appropriate for subcutaneous shot.
  • Encourage clients on the risk of blood borne illness and supply suggestions on whom to speak to if the client is worried that they might have exposed themselves to a blood birthed disease by sharing needles.
  • A list of drug stores joining your area is readily available with the Medications helpline 1800 459 459.

Safe disposal.

The pack likewise contains a tiny sharps container for utilized sharps. Pharmacies will certainly approve utilized sharps if returned in the sharps container.

Contamination and instability of product.

  • The quantity of item in the vial might differ considerably, might be polluted with microorganisms or various other chemicals.
  • Check the vial prior to use and also do not utilize if blemished or if bits visible.
  • It needs to be saved in the fridge.
  • All drugs need to be stayed out of the reach of children which may be challenging in a fridge.


  • Advise that side-effects are unknown, as well as the doses being utilized may not be secure.
  • Impacts of the medicine on an expected child are unidentified.
  • Effects when taken with other medications are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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