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Suggestions on the use on injecting tanning representatives, e.g. Melanotan


Due to the recent publicity as well as warnings concerning the threats of injecting melanotan the HSE has actually launched details and also recommendations on the use on injecting tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based upon a drug (afamelanotide) which was developed by the University of Arizona in 1981 to be utilized for photo defense against sunlight damage. This medicine is presently undergoing clinical tests for use in patients with particular sun-sensitive skin conditions and is not offered for general sale.

The drug is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a crucial function in figuring out skin as well as hair pigmentation, increases manufacturing of melanin in the skin, leading to a ‘sunlight tan’.

Melanotan is an artificial analog of α-MSH as well as is unlawful, untested and also uncontrolled which is currently being marketed online for self-administration. α-MSH is very delicate and also calls for a rigorous manufacturing environment which can not be assured in unlicensed production laboratories. The product should likewise be saved in a refrigerator.

What is the difference in between Melanotan I and Melanotan II?

Melanotan I specifically binds to receptors in charge of tanning and so has less adverse effects. Nevertheless much more of it is needed for result and therefore it is a lot more costly than Melanotan II.

Melanotan II binds to receptors aside from those in charge of tanning as well as for that reason leads to more side-effects.

What are the side-effects?

As this is an unregulated and untried medicine the complete series of potential side-effects are unknown. Enhanced sex drive, spontaneous erections, nausea (with succeeding weight-loss), face flushing on management, flu-like signs, and also raised blood pressure have been reported.

How is Melanotan provided?

Melanotan is administered subcutaneously by injecting into the fatty layer of cells around the tummy button area. Customers infuse daily until a preferred colour is achieved and afterwards continue to inject once or twice a week to keep the colour.

Some darkening of the skin may occur making use of the shot alone yet the effects are much more remarkable when made use of together with direct exposure to UV light (sunlight or tanning bed) 2-3 times a week at first and after that 1-2 times a week after that.

Exactly how is Melanotan offered?

Products on the marketplace include:

  • A multi- dosage vial of 10, 20 or 30 doses for subcutaneous shot.
  • A collection of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Main problems

Product pureness as well as web content:

  • This is an unlicensed, unregulated item. This is a vulnerable medicine which requires refrigeration.
  • Users might unwilling to place the item in their family fridge. If pre-filled syringes are positioned in the fridge this has effects in terms of access of youngsters to syringes.

Unidentified side-effects:

  • There are no scientific tests available on the short and long-term impacts of using these items or if the doses recommended by makers are risk-free.
  • There is no trial data available on exactly how these products might connect with various other medicines or their effect on an expected kid.

Injecting devices

  • Needles used to inject can also carry bodily liquids, which can hand down infections such as HIV and liver disease. In some cases, there is an undersupply of needles by the online vendors for the quantity of administration required, e.g. 1 needle supplied with a 10 dosage vial.
  • This can bring about sharing and recycling of needles. There are reports of customers making use of the very same needle for a month and attempting to sterilise after every use.
  • A multi-dose vial manufactured in a non-rigorous production setting might not remain clean and sterile for the duration of its use e.g. a 30mg vial is made to be made use of for 30 dosages which might extend a time period of 10 weeks.
  • Some sites provide pre-filled syringes in which the product is already re-constituted with bacteriostatic water, nevertheless there is no assurance that these pre-filled items will certainly continue to be secure and also clean and sterile during delivery or for the lifetime of their use.

Disposal of used sharps

There have actually been reports of needles being thrown away in home rubbish.

Boosted direct exposure to UV rays

As the effects of the tanning representatives are extra dramatic when made use of together with direct exposure to UV light (by all-natural sunshine or by tanning beds) use the representatives might raise UV direct exposure with all the addition threats associated such as boosted danger of skin cancer, skin ageing, and so on

Harm decrease activities

  • Describe to users concerning the risks related to injectable tanning items.
  • Highlight the risks related to increased UV exposure (the sick impacts of sun tanning still occur even in clients that have a deep tan). Clients can contact the Irish Cancer Society if they have problems concerning skin cancer on the cancer helpline 1800 200 700 or www.cancer.ie
  • Encourage individuals to quit making use of, and to seek medical advice if needed.

If making use of

Clean injecting equipment:

  • Recommend that they make use of a tidy needle each time and throw away needles in a sharps container. The needles available in the infusing pack available in drug stores joining the Pharmacy Needle Exchange Program are developed like a diabetic needle and also appropriate for subcutaneous injection.
  • Encourage customers on the risk of blood birthed illness as well as offer advice on whom to speak to if the customer is concerned that they may have revealed themselves to a blood borne illness by sharing needles.
  • A checklist of pharmacies taking part in your location is readily available via the Medications helpline 1800 459 459.

Safe disposal.

The pack likewise has a tiny sharps container for utilized sharps. Drug stores will certainly approve made use of sharps if returned in the sharps container.

Impurity and instability of product.

  • The amount of product in the vial may vary substantially, might be infected with bacteria or other chemicals.
  • Examine the vial before use as well as do not use if blemished or if bits visible.
  • It has to be saved in the fridge.
  • All medicines should be shut out of the reach of children which may be hard in a fridge.


  • Advise that side-effects are unidentified, and also the dosages being utilized might not be safe.
  • Impacts of the drug on an unborn kid are unknown.
  • Results when taken with other medications are unidentified.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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