Why was Melanotan invented?


When you tan your entire body, you’re revealing all your skin to hazardous UV rays. If your skin routinely gets subjected to UV rays excessive, it’ll trigger health concerns and also skin concerns for you.

The good news is, Melanotan peptide can help you deal with these tanning problems by enabling your body to increase its manufacturing of melanin. Whenever your body experiences UV damages, it normally responds by creating melanin. This is a peptide hormonal agent which naturally dims the skin in order to shield it from the damaging UV rays.


Recommendations on the usage on infusing tanning agents, e.g. Melanotan


Because of the current promotion and also warnings concerning the dangers of infusing melanotan the HSE has released info and also recommendations on the use on injecting tanning agents, e.g. Melanotan.

What is Melanotan?

Melanotan is based on a medication (afamelanotide) which was established by the University of Arizona in 1981 to be used for picture protection versus sun damage. This medication is presently undertaking scientific tests for usage in individuals with specific sun-sensitive skin disease and also is not available for basic sale.

The medication is chemically related to the alpha-melanocyte stimulating hormonal agent (α-MSH) and also binds to receptors (melanocortin receptors) in human skin cells. This binding to the α-MSH receptor, which has a vital role in establishing skin and also hair coloring, increases production of melanin in the skin, leading to a ‘sun tan’.

Melanotan is a synthetic analog of α-MSH and also is illegal, untried and uncontrolled which is presently being offered online for self-administration. α-MSH is extremely fragile as well as requires a rigorous production environment which can not be assured in unlicensed manufacturing research laboratories. The product needs to also be saved in a fridge.

What is the distinction in between Melanotan I and Melanotan II?

Melanotan I particularly binds to receptors responsible for tanning and so has less side effects. However far more of it is needed for impact and also consequently it is a lot more pricey than Melanotan II.

Melanotan II binds to receptors aside from those responsible for tanning and for that reason leads to more side-effects.

What are the side-effects?

As this is an unregulated and untried drug the full variety of possible side-effects are unidentified. Increased libido, spontaneous erections, queasiness (with subsequent weight-loss), facial flushing on administration, flu-like signs and symptoms, and also boosted blood pressure have actually been reported.

Exactly how is Melanotan carried out?

Melanotan is provided subcutaneously by infusing into the fatty layer of cells around the stubborn belly button location. Customers inject daily until a preferred colour is attained and afterwards continue to inject once or twice a week to preserve the colour.

Some darkening of the skin might occur making use of the shot alone but the results are even more dramatic when utilized in addition to direct exposure to UV light (sun or tanning bed) 2-3 times a week originally and after that 1-2 times a week thereafter.

Exactly how is Melanotan readily available?

Products on the marketplace include:

  • A multi- dose vial of 10, 20 or 30 doses for subcutaneous shot.
  • A set of pre-filled syringes for subcutaneous shot.
  • A nasal spray.

Main problems

Item pureness and content:

  • This is an unlicensed, uncontrolled product. This is a vulnerable medicine which calls for refrigeration.
  • Individuals may unwilling to place the product in their family fridge. If pre-filled syringes are positioned in the refrigerator this has effects in terms of accessibility of kids to syringes.

Unknown side-effects:

  • There are no medical tests readily available on the short and long-term results of using these products or if the doses advised by producers are secure.
  • There is no test data available on just how these products might connect with various other drugs or their result on an expected child.

Infusing devices

  • Needles made use of to inject might likewise lug bodily liquids, which can pass on infections such as HIV as well as hepatitis. In some cases, there is an undersupply of needles by the on the internet distributors for the amount of management required, e.g. 1 needle supplied with a 10 dosage vial.
  • This might cause sharing and also recycling of needles. There are records of customers utilizing the exact same needle for a month and trying to sterilise after every use.
  • A multi-dose vial produced in a non-rigorous production atmosphere may not continue to be clean and sterile for the duration of its usage e.g. a 30mg vial is designed to be made use of for 30 doses which may span a time period of 10 weeks.
  • Some websites supply pre-filled syringes in which the product is currently re-constituted with bacteriostatic water, nonetheless there is no warranty that these pre-filled products will certainly continue to be steady as well as sterile during shipment or for the lifetime of their usage.

Disposal of used sharps

There have been reports of needles being gotten rid of in family rubbish.

Raised direct exposure to UV rays

As the impacts of the tanning agents are extra significant when made use of combined with exposure to UV light (by natural sunlight or by tanning beds) use of the representatives might enhance UV direct exposure with all the enhancement dangers connected such as increased threat of skin cancer cells, skin ageing, etc

Injury reduction activities

  • Discuss to users regarding the dangers connected with injectable tanning items.
  • Highlight the risks related to boosted UV direct exposure (the ill effects of tanning still take place even in clients who have a deep tan). Customers can contact the Irish Cancer Society if they have worries concerning skin cancer cells on the cancer helpline 1800 200 700 or www.cancer.ie
  • Urge individuals to quit making use of, and to seek clinical suggestions if needed.

If using

Clean injecting equipment:

  • Recommend that they utilize a tidy needle every time and also deal with needles in a sharps container. The needles offered in the injecting pack readily available in drug stores participating in the Pharmacy Needle Exchange Program are made like a diabetic needle as well as appropriate for subcutaneous shot.
  • Advise customers on the risk of blood borne conditions and also use recommendations on whom to call if the client is worried that they might have exposed themselves to a blood borne disease by sharing needles.
  • A list of drug stores participating in your area is available with the Drugs helpline 1800 459 459.

Safe disposal.

The pack additionally contains a little sharps container for utilized sharps. Pharmacies will accept used sharps if returned in the sharps container.

Contamination and instability of item.

  • The quantity of product in the vial may differ significantly, might be polluted with bacteria or various other chemicals.
  • Inspect the vial before usage and do not make use of if tarnished or if particles noticeable.
  • It has to be kept in the fridge.
  • All medicines need to be shut out of the reach of children which may be tough in a fridge.


  • Encourage that side-effects are unknown, and the dosages being made use of may not be safe.
  • Effects of the medicine on an unborn child are unidentified.
  • Results when taken with other medications are unknown.


Melanotan in WikiPedia

Melanotan II is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH) that stimulates melanogenesis and increases sexual arousal.

It was under development as drug candidate for female sexual dysfunction and erectile dysfunction but clinical development ceased by 2003, and as of 2018, no product containing melanotan II was marketed and all commercial development had ceased.

Unlicensed, untested, or fraudulent products sold as “melanotan II” are found on the Internet, and purported to be effective as “tanning drugs”, though side effects such as uneven pigmentation (it makes already uneven pigmentation more noticeable), new nevi (moles), and darkening or enlargement of existing moles have been reported and have led to medical authorities discouraging its use. There has been no scientific study into the long term and permanent side effects the use of this peptide may cause.

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